Department of Clinical Medicine and Surgery, University of Naples Federico II Medical School, Italy.
Department of Clinical Medicine and Surgery, University of Naples Federico II Medical School, Italy.
Nutr Metab Cardiovasc Dis. 2021 Mar 10;31(3):756-761. doi: 10.1016/j.numecd.2020.12.001. Epub 2020 Dec 8.
In the course of the COVID-19 pandemic, multiple suggestions have been delivered through websites and social media referring to natural substances and various kinds of supplements with thaumaturgical properties in preventing and/or fighting the coronavirus infection. Indeed, there is no clinical trial evidence that a dietary or pharmacological supplementation of any particular substance will increase the effectiveness of the immune defences. There are however three nutritional issues that deserve special attention under the present circumstances, namely vitamin D deficiency, excess salt intake and inappropriate alcohol consumption. Here is a short review of the current knowledge about the possible role of these factors in the immunity defence system and their potential impact on the modulation of the immune response to SARS-COV2 infection.
For all of these factors there is convincing evidence of an impact on the immune defence structure and function. In the absence of RCT demonstration that increased ingestion of any given substance may confer protection against the new enemy, special attention to correction of these three nutritional criticisms is certainly warranted at the time of COVID pandemic.
We propose that the inappropriate intake of salt and alcohol and the risk of inadequate vitamin D status should be object of screening, in particular in subjects at high mortality risk from SARS-COV 2 infection, such as institutionalised elderly subjects and all those affected by predisposing conditions.
在 COVID-19 大流行期间,通过网站和社交媒体提出了多种建议,涉及具有神奇特性的天然物质和各种补充剂,以预防和/或对抗冠状病毒感染。事实上,没有临床试验证据表明任何特定物质的饮食或药物补充会增加免疫防御的有效性。然而,目前有三个营养问题值得特别关注,即维生素 D 缺乏、盐摄入过多和酒精摄入不当。以下是对这些因素在免疫防御系统中可能发挥的作用及其对 SARS-COV2 感染免疫反应调节的潜在影响的简要综述。
对于所有这些因素,都有令人信服的证据表明它们对免疫防御结构和功能有影响。在没有 RCT 证明增加任何特定物质的摄入可能对新敌人提供保护的情况下,在 COVID 大流行期间,特别需要注意纠正这三种营养批评。
我们建议,应筛查盐和酒精的不当摄入以及维生素 D 状态不足的风险,特别是在 SARS-COV2 感染死亡率高的人群中,如机构化的老年人群体和所有患有易患疾病的人群。