Honda Kazuya, Okazaki Kanako, Tanaka Kenichi, Kazama Junichiro J, Hashimoto Shigeatsu, Ohira Tetsuya, Sakai Akira, Yasumura Seiji, Maeda Masaharu, Yabe Hirooki, Suzuki Yuriko, Hosoya Mitsuaki, Takahashi Atsushi, Nakano Hironori, Hayashi Fumikazu, Nagao Masanori, Ohira Hiromasa, Shimabukuro Michio, Ohto Hitoshi, Kamiya Kenji
Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine, Fukushima, Japan; Department of Endocrinology, Metabolism, Diabetology, and Nephrology, Fukushima Medical University Aizu Medical Center, Aizuwakamatsu, Japan.
Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima, Japan; Preparing Section for New Faculty of Medical Science Fukushima Medical University, Fukushima, Japan.
Nutr Metab Cardiovasc Dis. 2021 Apr 9;31(4):1177-1188. doi: 10.1016/j.numecd.2020.12.016. Epub 2021 Feb 3.
On March 11, 2011, the Great East Japan Earthquake occurred in Japan, with a nuclear accident subsequently occurring at the Fukushima Daiichi Nuclear Power Plant. The disaster forced many evacuees to change particular aspects of their lifestyles. This study assessed the association between evacuation and hyperuricemia based on the Fukushima Health Management Survey from a lifestyle and socio-psychological perspective.
This cross-sectional study included 22,812 residents (9391 men and 13,297 women) who underwent both the Comprehensive Health Check and the Mental Health and Lifestyle Survey in fiscal year 2011. Associations between hyperuricemia and lifestyle- and disaster-related factors including evacuation were estimated using a logistic and liner regression analysis. With hyperuricemia defined as uric acid levels >7.0 mg/dL for men and >6.0 mg/dL for women, significant associations were observed between evacuation and hyperuricemia in men (the multivariate-adjusted odds ratio 1.20, 95% confidence interval, 1.05-1.36, p = 0.005), but not in women. In the multivariate-adjusted multiple liner regression analysis, evacuation had significant and positive associations with uric acid levels both in men (β = 0.084, p = 0.002) and women (β = 0.060, p < 0.001).
Evacuation after a natural disaster is an independent factor associated with hyperuricemia.
2011年3月11日，日本发生东日本大地震，随后福岛第一核电站发生核事故。这场灾难迫使许多撤离者改变了生活方式的某些方面。本研究基于福岛健康管理调查，从生活方式和社会心理角度评估了撤离与高尿酸血症之间的关联。
这项横断面研究纳入了2011财年同时接受综合健康检查以及心理健康与生活方式调查的22812名居民（9391名男性和13297名女性）。使用逻辑回归和线性回归分析评估高尿酸血症与包括撤离在内的生活方式和灾害相关因素之间的关联。将男性尿酸水平>7.0mg/dL、女性尿酸水平>6.0mg/dL定义为高尿酸血症，结果观察到男性撤离与高尿酸血症之间存在显著关联（多变量调整优势比1.20，95%置信区间为1.05 - 1.36，p = 0.005），而女性则未观察到这种关联。在多变量调整的多元线性回归分析中，撤离与男性（β = 0.084，p = 0.002）和女性（β = 0.060，p < 0.001）的尿酸水平均存在显著正相关。
自然灾害后的撤离是与高尿酸血症相关的一个独立因素。
