Department of Physical Education, Federal University of Sergipe, SE, Brazil.
Department of Physical Education, Federal Rural University of Pernambuco, PE, Brazil.
Ann Vasc Surg. 2021 Jul;74:382-388. doi: 10.1016/j.avsg.2020.12.049. Epub 2021 Feb 5.
Exercise program has been recommended for the treatment of symptomatic peripheral artery disease (PAD) patients. However, whether exercise promotes reduction in arterial stiffness in these patients, who exhibit high arterial stiffness, is poor known.
To analyze the effects of a single session of resistance, walking, and combined exercises on arterial stiffness in symptomatic PAD patients and to describe individual responses and identify clinical predictors of arterial stiffness responses after exercises.
Twelve patients with symptomatic PAD underwent four experimental sessions in random order: walking exercise (W - 10 bouts of 2-min walking at the speed corresponding to the onset of claudication pain with 2-min interval among sets), resistance exercise (R - 2 sets of 10 reps in eight resistance exercises), combined exercise (CO - 1 set of 10 reps in eight resistance exercises + 5 bouts of 2-min walking with 2-min interval between) and control session (C - resting in exercise room). Ambulatory arterial stiffness index (AASI) was obtained during ambulatory period after each session. Body mass index, ankle brachial index, sex and age also were evaluated.
AASI was lower in R compared to other sessions (R - 0.52 ± 0.05; W - 0.59 ± 0.05; CO - 0.64 ± 0.05; C - 0.60 ± 0.05, P < 0.001), with 75% of patients presenting lower AASI after R session. No difference was found between W, CO and C sessions (P> 0.05). Ankle brachial index was negatively correlated with R and W sessions net effect (r = -0.618 and -0.750, respectively; P< 0.05 for both), no correlation was found with CO.
A single bout of resistance exercise acutely reduces arterial stiffness in symptomatic PAD, while walking and combined exercise did not alter this variable. This response is more likely to occur in individuals with less severe disease.
运动方案已被推荐用于治疗有症状的外周动脉疾病（PAD）患者。然而，对于那些表现出高动脉僵硬的患者，运动是否能促进动脉僵硬的减少尚不清楚。
分析单次抗阻、步行和组合运动对有症状的 PAD 患者动脉僵硬的影响，并描述个体反应，确定运动后动脉僵硬反应的临床预测因子。
12 例有症状的 PAD 患者随机接受 4 个实验疗程：步行运动（W-10 组 2 分钟步行，每组间隔 2 分钟，速度对应跛行疼痛发作；）、抗阻运动（R-8 种抗阻运动 2 组，每组 10 次）、组合运动（CO-8 种抗阻运动 1 组，每组 10 次+5 组 2 分钟步行，每组间隔 2 分钟）和对照疗程（C-在运动室休息）。在每个疗程后的动态期间获得动态动脉僵硬指数（AASI）。还评估了体重指数、踝臂指数、性别和年龄。
与其他疗程相比，R 疗程的 AASI 较低（R-0.52±0.05；W-0.59±0.05；CO-0.64±0.05；C-0.60±0.05，P<0.001），75%的患者在 R 疗程后 AASI 较低。W、CO 和 C 疗程之间无差异（P>0.05）。踝臂指数与 R 和 W 疗程的净效应呈负相关（r分别为-0.618 和-0.750，均为 P<0.05），与 CO 无相关性。
单次抗阻运动可急性降低有症状的 PAD 患者的动脉僵硬，而步行和组合运动不会改变该变量。这种反应更可能发生在疾病程度较轻的个体中。
