Haas F, Levine N, Axen K, Perelman S I, Pineda H, Haas A
Department of Rehabilitation Medicine, New York University School of Medicine, New York.
Am Rev Respir Dis. 1988 Apr;137(4):833-6. doi: 10.1164/ajrccm/137.4.833.
Adrenergic mechanisms modulate exercise-induced changes in blood serum K+ concentration ([K+]). Impairment of these same mechanisms may be associated with bronchial hyper-reactivity. If this is accurate, asthmatic subjects should show disturbed K+ regulation during exercise. We measured [K+] and FEV1 in 13 healthy control and in 13 asthmatic subjects pre-exercise, at peak exercise (within 1 min of stopping exercise), and 10 min postexercise. This was done on 2 separate days, one with and one without bronchodilator (BD) pretreatment. Both groups were equally fit, exercising to the same O2 consumption and heart rate. Resting [K+] was normal for both groups (two-day averages were 4.00 +/- 0.07 and 4.09 +/- 0.07 mmol/L, mean +/- SEM, in control and asthmatic subjects, respectively). Without BD pretreatment, at peak exercise, [K+] in control subjects rose by 0.56 +/- 0.08 compared with 0.96 +/- 0.09 in asthmatics (p less than 0.01). After exercise, [K+] returned to baseline (4.12 +/- 0.08) in control subjects but remained elevated in asthmatics (4.60 +/- 0.12, p less than 0.01). Although FEV1 was unchanged in control subjects, in asthmatics it fell after exercise (p less than 0.01). With BD pretreatment: peak exercise [K+] increased by 0.55 +/- 0.09 in control subjects, and by 0.49 +/- 0.01 in asthmatics (p less than 0.01). By 10 min postexercise, it returned to baseline in both groups (4.15 +/- 0.11 for control subjects and 4.32 +/- 0.07 for asthmatics). The asthma group's fall in FEV1 was also abolished. These data indicate that postexercise K+ remains elevated in asthmatics, supporting the suggestion that their adrenergic function is impaired.
肾上腺素能机制调节运动引起的血清钾离子浓度（[K+]）变化。这些相同机制的受损可能与支气管高反应性有关。如果这一说法正确，那么哮喘患者在运动期间应表现出钾离子调节紊乱。我们测量了13名健康对照者和13名哮喘患者在运动前、运动高峰时（停止运动后1分钟内）以及运动后10分钟的[K+]和第一秒用力呼气容积（FEV1）。这在两个不同的日子进行，一天进行支气管扩张剂（BD）预处理，另一天不进行。两组的身体状况相当，运动至相同的耗氧量和心率。两组的静息[K+]均正常（对照组和哮喘患者的两天平均值分别为4.00±0.07和4.09±0.07毫摩尔/升，均值±标准误）。在没有BD预处理的情况下，运动高峰时，对照组的[K+]升高了0.56±0.08，而哮喘患者为0.96±0.09（p<0.01）。运动后，对照组的[K+]恢复到基线水平（4.12±0.08），而哮喘患者仍保持升高（4.60±0.12，p<0.01）。虽然对照组的FEV1没有变化，但哮喘患者运动后FEV1下降（p<0.01）。进行BD预处理后：运动高峰时，对照组的[K+]升高了0.55±0.09，哮喘患者升高了0.49±0.01（p<0.01）。到运动后10分钟，两组均恢复到基线水平（对照组为4.15±0.11，哮喘患者为4.32±0.07）。哮喘组FEV1的下降也被消除。这些数据表明，哮喘患者运动后钾离子仍保持升高，支持了其肾上腺素能功能受损的观点。
