Department of Immunology, University of Tübingen, Tübingen, Germany; Health Sciences North Research Institute, Sudbury, Ontario, Canada.
Health Sciences North Research Institute, Sudbury, Ontario, Canada.
Cell Immunol. 2021 Apr;362:104297. doi: 10.1016/j.cellimm.2021.104297. Epub 2021 Jan 30.
The challenge of distinguishing between changes attributable to ageing and those attributable to pathology is even greater for the immune system than for many other organs, and this is especially true for myeloid-derived suppressor cells (MDSCs). Hematopoiesis is different in older adults with a bias towards myelopoiesis, and older adults also manifest "inflammageing" exacerbated by disease and contributing to MDSC induction. Hence, at least in humans, one can only investigate MDSCs in the context of ageing and disease states, and not in the context of ageing processes per se. This contribution provides a brief overview of the literature on MDSCs and ageing in humans.
区分衰老引起的变化和病理引起的变化的挑战对于免疫系统来说甚至比许多其他器官更大，对于髓系来源的抑制细胞（MDSCs）尤其如此。老年人的造血过程偏向于髓样生成，并且老年人还表现出“炎症衰老”，这种衰老被疾病加剧，并导致 MDSC 的诱导。因此，至少在人类中，人们只能在衰老和疾病状态的背景下研究 MDSCs，而不能在衰老过程本身的背景下研究。本综述简要概述了人类 MDSCs 与衰老的文献。
