Yeger H, Minaker E, Charles D, Rubin A, Sturgess J M
Department of Pathology, Hospital for Sick Children, Toronto, Canada.
Ann Otol Rhinol Laryngol. 1988 Mar-Apr;97(2 Pt 1):186-91. doi: 10.1177/000348948809700217.
We studied the fine structure of nasal and middle ear mucosa in 18 patients with chronic otitis media, comparing them with ten age-matched control patients. Electron microscopy revealed no single fundamental defect of cilia in the tissue samples; however, patients with chronic otitis media had a significantly higher incidence of abnormal cilia in the middle ear without correlating abnormalities of nasal cilia. These findings indicated that ciliary anomalies, including deletion of ciliary microtubules, presence of supernumerary tubules, and fusion of cilia, occur as a result of infection or inflammation. Such abnormalities would impair normal mucociliary clearance and exacerbate clinical complications.
我们研究了18例慢性中耳炎患者的鼻和中耳黏膜的精细结构，并与10例年龄匹配的对照患者进行比较。电子显微镜检查显示组织样本中纤毛没有单一的基本缺陷；然而，慢性中耳炎患者中耳中异常纤毛的发生率显著更高，而鼻纤毛没有相关异常。这些发现表明，包括纤毛微管缺失、多余微管存在和纤毛融合在内的纤毛异常是感染或炎症的结果。这种异常会损害正常的黏液纤毛清除功能并加重临床并发症。
