Ikeda K
First Department of Surgery, Iwate Medical University, Morioka, Japan.
Nihon Geka Gakkai Zasshi. 1991 Apr;92(4):387-96.
SCC-RA is one of the fractions of TA-4, extracted and purified from uterine cervical squamous cell carcinoma. I studied SCC-RA in order to evaluate its significance as a tumor marker for esophageal carcinoma. In 32 of 75 (42.7%) esophageal cancer patients, serum SCC-RA was positive. As compared with IAP and CEA, SCC-RA was the best marker to monitor esophageal cancer. SCC-RA positive patients tended to die earlier than negative ones, and it was considered to be one of the prognostic factors. In the immunohistochemical study using anti SCC-RA monoclonal antibody, both the normal epithelium and the carcinoma tissue reacted with SCC-RA. In the carcinoma tissue. SCC-RA reactivity was observed in 27 of 31 specimens (87%). However there was no correlation among the reactivity, the serum level and clinical stage. Furthermore, I studied the relationship between the tumor growth and the serum SCC-RA levels in the nude mice bearing human esophageal squamous cell carcinoma xenografts. The SCC-RA levels in mice sera gradually increased and they correlated well to the tumor volume. In conclusion, SCC-RA reflected the tumor volume and clinical stage, and SCC-RA is useful for monitoring esophageal cancer patients.
SCC - RA是从子宫颈鳞状细胞癌中提取并纯化的TA - 4的一种组分。我研究SCC - RA是为了评估其作为食管癌肿瘤标志物的意义。75例食管癌患者中有32例（42.7%）血清SCC - RA呈阳性。与IAP和CEA相比，SCC - RA是监测食管癌的最佳标志物。SCC - RA阳性患者往往比阴性患者死亡更早，它被认为是预后因素之一。在使用抗SCC - RA单克隆抗体的免疫组织化学研究中，正常上皮和癌组织均与SCC - RA发生反应。在癌组织中，31个标本中有27个（87%）观察到SCC - RA反应性。然而，反应性、血清水平和临床分期之间没有相关性。此外，我研究了携带人食管鳞状细胞癌异种移植物的裸鼠中肿瘤生长与血清SCC - RA水平之间的关系。小鼠血清中的SCC - RA水平逐渐升高且与肿瘤体积密切相关。总之，SCC - RA反映了肿瘤体积和临床分期，对监测食管癌患者有用。
