Wu Zhuoying, Luo Qianyi, Wu Huawang, Wu Zhiyao, Zheng Yingjun, Yang Yuling, He Jianfei, Ding Yi, Yu Rongjun, Peng Hongjun
Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Front Psychiatry. 2021 Jan 22;11:596337. doi: 10.3389/fpsyt.2020.596337. eCollection 2020.
Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.
伴有童年创伤的重度抑郁症（MDD）是抑郁症的功能亚型之一。已有报道称MDD患者低频波动幅度（ALFF）存在频率依赖性变化。然而，关于伴有童年创伤的MDD的ALFF研究较少。采用静息态功能磁共振成像测量了69例伴有童年创伤的MDD患者（28.7±9.6岁）和30名健康受试者（28.12±4.41岁）的ALFF。分析了两个频段（慢波5：0.010 - 0.027Hz；慢波4：0.027 - 0.073Hz）。与对照组相比，伴有童年创伤的MDD患者左侧S1（初级体感皮层）的ALFF降低，左侧岛叶的ALFF增加。更重要的是，在右侧背侧前扣带回皮层（dACC）发现了显著的组×频率交互作用。我们的发现可能为伴有童年创伤的MDD的病理生理学提供见解。
