Samiei Niloufar, Akiash Nehzat, Djafari Naeini Sepideh, Nikpajouh Akbar, Pazoki Mahboubeh
Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
J Tehran Heart Cent. 2020 Jul;15(3):98-104. doi: 10.18502/jthc.v15i3.4218.
The superior type of sinus venosus atrial septal defect (SVASD) is a rare form of the atrial septal defect (ASD) in which the upper part of the atrial septum does not exist. The presence of other cardiac anomalies such as anomalous pulmonary venous connections has been reported in this type of congenital heart disease. This study aimed to assess the presence of the patent foramen ovale (PFO) in patients with the superior type of SVASD. This retrospective case-control study on 387 patients, consisting of 187 patients with a definite SVASD and 200 patients with problems other than the ASD, was conducted in Rajaie Cardiovascular Medical and Research Center between February 2005 and July 2014. Seven patients with inadequate data were excluded from the analysis. The presence/absence of the PFO was also evaluated in the case and control groups. The analyses were performed on 182 male and 198 female patients at a mean age of 39.07±14.41 and 51.01±15.80 years in the case and control groups, respectively. The PFO was significantly more frequent in the patients with the superior type of SVASD than in those without the condition (P<0.001). The persistence of the left superior vena cava was seen in 34 out of 180 patients with SVASD and in 1 out of 200 patients without the condition (18.9% vs 0.5%; P<0.001). This study was the first to highlight the coexistence of the PFO and the superior type of SVASD. Physiological, genetic, or fetal factors may play an important role in the association between the PFO and the SVASD.
上腔型静脉窦型房间隔缺损（SVASD）是房间隔缺损（ASD）的一种罕见形式，其中房间隔的上部不存在。在这种先天性心脏病类型中，已报告存在其他心脏异常，如肺静脉连接异常。本研究旨在评估上腔型SVASD患者中卵圆孔未闭（PFO）的存在情况。这项回顾性病例对照研究于2005年2月至2014年7月在拉贾伊心血管医学与研究中心对387例患者进行，其中包括187例确诊的SVASD患者和200例患有ASD以外问题的患者。7例数据不充分的患者被排除在分析之外。还在病例组和对照组中评估了PFO的存在与否。分别对病例组和对照组中平均年龄为39.07±14.41岁和51.01±15.80岁的182例男性和198例女性患者进行了分析。上腔型SVASD患者中PFO的发生率明显高于无该疾病的患者（P<0.001）。180例SVASD患者中有34例存在左上腔静脉持续存在，而200例无该疾病的患者中有1例存在（18.9%对0.5%；P<0.001）。本研究首次强调了PFO与上腔型SVASD的共存。生理、遗传或胎儿因素可能在PFO与SVASD之间的关联中起重要作用。
