Jin Yuelei, Qi Gangqiao, Chen Guang, Wang Chen, Fan Xiaoyan
Department of Basic Medical Sciences, Taizhou University, Taizhou, Zhejiang 318000, P.R. China.
Department of Sleep Medicine Center, Taizhou Second People's Hospital, Taizhou, Zhejiang 317200, P.R. China.
Oncol Lett. 2021 Feb;21(2):166. doi: 10.3892/ol.2021.12427. Epub 2021 Jan 4.
B-Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B-Myb promotes tumor formation and development. B- is a proto-oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tumorigenesis and aging. In addition, B- is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development. B- expression is also associated with the prognosis of patients with malignant tumors. Both microRNAs and E2F family of transcription factors (E2Fs) contribute to the function of B-Myb. The present review highlights the association between B- and malignant tumors, and offers a theoretical reference for the diagnosis and treatment of malignant tumors.
B-Myb是调节细胞周期的关键转录因子。B-Myb表达失调促进肿瘤的形成和发展。B-Myb是一种原癌基因，在增殖细胞中普遍表达，维持正常的细胞周期进程。它参与细胞凋亡、肿瘤发生和衰老。此外，B-Myb在包括乳腺癌、肺癌和肝细胞癌在内的多种恶性肿瘤中过表达，并与肿瘤发展相关。B-Myb的表达也与恶性肿瘤患者的预后相关。微小RNA和转录因子E2F家族（E2Fs）均对B-Myb的功能有影响。本综述着重阐述了B-Myb与恶性肿瘤之间的关联，为恶性肿瘤的诊断和治疗提供理论参考。
