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异丙酚通过抑制 MIR155HG 抑制宫颈癌细胞的生长和侵袭。

Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG.

机构信息

Department of Anesthesia and Perioperative Medicine, Zaozhuang Municipal Hospital, Zaozhuang, Shandong, People's Republic of China.

Department of Gynecology and Obstetrics, Zaozhuang Hospital, Zaozhuang Mining Group, Zaozhuang, Shandong, People's Republic of China.

出版信息

Aging (Albany NY). 2021 Nov 13;13(21):24464-24475. doi: 10.18632/aging.203697.

DOI:10.18632/aging.203697
PMID:34775376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8610141/
Abstract

BACKGROUND

Cervical cancer is the most prevalent malignancy worldwide and propofol reportedly has anti-cancer efficiencies. Herein, we tried to address the potential anti-cancer effects of propofol in cervical carcinoma.

MATERIALS AND METHODS

The suppression effects of propofol on the proliferation and invasion of cervical cancer cells were analyzed by Cell Counting Kit-8 (CCK-8), colony formation and Transwell invasion assay. The protein expressions of epithelial marker, E-cadherin and mesenchymal marker, N-cadherin were evaluated using western blot. The level of MIR155 host gene (MIR155HG) was determined by qRT-PCR assay. The anti-cancer impact of propofol on cervical cancer cells growth was determined by means of xenograft tumor model and lung metastasis model.

RESULTS

, propofol inhibited the growth and colony-formation of cervical carcinoma cells. Meanwhile, propofol treatment reduced the invasive trait of cervical carcinoma cells. In addition, MIR155HG was identified to be distinctly upregulated in cervical carcinoma when compared within normal. Propofol treatment decreased the expression of MIR155HG in cervical cancer cells. Consistently, the results from xenograft model indicated that propofol repressed cervical cancer cells growth and decreased the expression of MIR155HG . Furthermore, reintroduction of MIR155HG into cervical cancer cells counteracted the inhibitory potency of propofol on the growth and aggressive phenotypes in cervical carcinoma cells.

CONCLUSIONS

Altogether, these results indicated that propofol restrained the growth and invasion of cervical cancer cells partly via regulating MIR155HG expression.

摘要

背景

宫颈癌是全球最常见的恶性肿瘤，据报道丙泊酚具有抗癌作用。在此，我们试图探讨丙泊酚在宫颈癌中的潜在抗癌作用。

材料与方法

通过细胞计数试剂盒（CCK-8）、集落形成和 Transwell 侵袭实验分析丙泊酚对宫颈癌细胞增殖和侵袭的抑制作用。用 Western blot 检测上皮标志物 E-钙黏蛋白和间充质标志物 N-钙黏蛋白的蛋白表达。用 qRT-PCR 检测 MIR155 宿主基因（MIR155HG）的水平。通过异种移植肿瘤模型和肺转移模型确定丙泊酚对宫颈癌细胞生长的抗癌影响。

结果

丙泊酚抑制宫颈癌细胞的生长和集落形成。同时，丙泊酚处理降低了宫颈癌细胞的侵袭特性。此外，与正常组织相比，MIR155HG 在宫颈癌中明显上调。丙泊酚处理降低了宫颈癌细胞中 MIR155HG 的表达。同样，异种移植模型的结果表明，丙泊酚抑制宫颈癌细胞生长并降低 MIR155HG 的表达。此外，将 MIR155HG 重新引入宫颈癌细胞中可拮抗丙泊酚对宫颈癌细胞生长和侵袭表型的抑制作用。

结论

综上所述，这些结果表明，丙泊酚通过调节 MIR155HG 的表达部分抑制了宫颈癌细胞的生长和侵袭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/d9298aded1d8/aging-13-203697-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/72745bb7b05e/aging-13-203697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/257332d6b22a/aging-13-203697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/4cb0a5c9f813/aging-13-203697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/47a76b3c3d65/aging-13-203697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/d9298aded1d8/aging-13-203697-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/72745bb7b05e/aging-13-203697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/257332d6b22a/aging-13-203697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/4cb0a5c9f813/aging-13-203697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/47a76b3c3d65/aging-13-203697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/792b/8610141/d9298aded1d8/aging-13-203697-g005.jpg

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