真菌诱导的噬血细胞性淋巴组织细胞增生症：非HIV人群的文献综述
Fungal-Induced Hemophagocytic Lymphohistiocytosis: A Literature Review in Non-HIV Populations.
作者信息
Chiu Chia-Yu, Hicklen Rachel S, Kontoyiannis Dimitrios P
机构信息
Division of Infectious Diseases, Department of Medicine, University of Colorado, Aurora, CO 80045, USA.
Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
J Fungi (Basel). 2025 Feb 18;11(2):158. doi: 10.3390/jof11020158.
We performed a thorough search of the literature published through December 2024 with no date exclusions on invasive fungal infection (IFI)-induced hemophagocytic lymphohistiocytosis (HLH) in non-human immunodeficiency virus (HIV) patients. The frequency of IFI-induced HLH reported across 16 articles was 9%. Of the 116 identified cases with available clinical information, 53% occurred in immunocompromised patients. IFIs were usually disseminated (76%), with being the most common pathogen (51%). IFI and HLH were diagnosed simultaneously in most cases (78%). The 30-day survival rate was 64%. Reported cases had significant heterogeneity in patient characteristics, management strategies, and outcomes.
我们对截至2024年12月发表的文献进行了全面检索，不排除任何日期，以研究非人类免疫缺陷病毒（HIV）患者中侵袭性真菌感染（IFI）诱发的噬血细胞性淋巴组织细胞增生症（HLH）。16篇文章报道的IFI诱发HLH的发生率为9%。在116例有可用临床信息的确诊病例中，53%发生在免疫功能低下的患者中。IFI通常为播散性感染（76%），其中 是最常见的病原体（51%）。大多数病例（78%）中IFI和HLH是同时诊断的。30天生存率为64%。报告的病例在患者特征、管理策略和结局方面存在显著异质性。
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