Saffarzadeh Mohammadali, Mulpuri Anvith, Arneja Jugpal S
Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
St. George's School, Vancouver, BC, Canada.
Plast Reconstr Surg Glob Open. 2021 Jan 22;9(1):e3382. doi: 10.1097/GOX.0000000000003382. eCollection 2021 Jan.
Here, we present the case of an adolescent male who developed a severe allergic reaction 10 minutes after application of TISSEEL fibrin sealant to control bleeding during a gynecomastia revision surgery. Conventional treatments of acute hypersensitivity were ineffective. After a "tisseel-ectomy," the patient's condition improved and symptoms resolved. Besides oral tranexamic acid, and topical and local anaesthesia, no other medications besides TISSEEL were administered preceding the allergic reaction. After TISSEEL was identified as the allergen upon its removal, his clinical status improved. The patient had been exposed to TISEEL 15 months before the anaphylactic episode. This case can aid in decision-making for surgical re-exposure to fibrin sealants in the setting of acute anaphylaxis.
在此，我们报告一例青春期男性病例，该患者在男性乳房肥大修复手术中应用TISSEEL纤维蛋白封闭剂控制出血10分钟后出现严重过敏反应。急性超敏反应的常规治疗无效。在进行“TISSEEL切除术”后，患者病情改善，症状缓解。除口服氨甲环酸以及局部外用和局部麻醉外，在过敏反应发生前，除TISSEEL外未使用其他药物。在移除TISSEEL后确定其为过敏原，患者的临床状况得到改善。该患者在过敏反应发作前15个月接触过TISSEEL。该病例有助于在急性过敏反应情况下决定是否再次进行手术暴露于纤维蛋白封闭剂。
