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2
SGLT2 inhibitors for non-diabetic kidney disease: drugs to treat CKD that also improve glycaemia.用于非糖尿病肾病的钠-葡萄糖协同转运蛋白2抑制剂:治疗慢性肾脏病且能改善血糖水平的药物。
Clin Kidney J. 2020 Oct 9;13(5):728-733. doi: 10.1093/ckj/sfaa198. eCollection 2020 Oct.
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Health Care Policy After the COVID-19 Pandemic.新冠疫情后的医疗保健政策。
JAMA. 2020 Jul 21;324(3):233-234. doi: 10.1001/jama.2020.10777.
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Inflammation and Premature Ageing in Chronic Kidney Disease.慢性肾脏病中的炎症与早衰
Toxins (Basel). 2020 Apr 4;12(4):227. doi: 10.3390/toxins12040227.
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LDL cholesterol: lower, faster, younger?低密度脂蛋白胆固醇:更低、更快、更年轻化?
Lancet Diabetes Endocrinol. 2020 Jan;8(1):5-7. doi: 10.1016/S2213-8587(19)30389-4.
6
Modifying Phosphate Toxicity in Chronic Kidney Disease.改善慢性肾脏病中的磷毒性
Toxins (Basel). 2019 Sep 9;11(9):522. doi: 10.3390/toxins11090522.
7
Impact of Recent Clinical Trials on Nephrology Practice: Are We in a Stagnant Era?近期临床试验对肾脏病学实践的影响:我们正处于停滞时代吗?
Kidney Dis (Basel). 2019 Mar;5(2):69-80. doi: 10.1159/000495139. Epub 2018 Dec 19.
8
Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis.血清镁、死亡率与慢性肾脏病和终末期肾病患者的心血管疾病:系统评价和荟萃分析。
J Nephrol. 2019 Oct;32(5):791-802. doi: 10.1007/s40620-019-00601-6. Epub 2019 Mar 19.
9
KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).KDIGO 2017慢性肾脏病-矿物质和骨异常(CKD-MBD)诊断、评估、预防及治疗临床实践指南更新
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10
The Emperor's New Clothes: a Critical Appraisal of Evidence-based Medicine.《皇帝的新装:对循证医学的批判性评价》
Int J Med Sci. 2018 Sep 7;15(12):1397-1405. doi: 10.7150/ijms.25869. eCollection 2018.

新冠疫情时代的“帝王综合征”:以患者为中心的肾脏病学时机已到?

Emperor's syndrome in the COVID-19 era: Time for patient-centered nephrology?

作者信息

Bacharaki Dimitra, Diamandopoulos Athanasios

机构信息

Department of Nephrology, Attikon University Hospital, Chaidari 12462, Greece.

EKPA, Louros Foundation for the History of Medicine, Chaidari 12462, Greece.

出版信息

World J Nephrol. 2021 Jan 25;10(1):1-7. doi: 10.5527/wjn.v10.i1.1.

DOI:10.5527/wjn.v10.i1.1
PMID:33552939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7829681/
Abstract

The coronavirus disease-19 (COVID-19) pandemic has been a wake-up call in which has forced us to react worldwide. Health policies and practices have attracted particular attention in terms of human and financial cost. Before COVID-19, chronic kidney disease was already considered a risk multiplier in patients with diabetes and hypertension, the two now being the major risk factors for COVID-19 infection and adverse outcome. In contrast to the urgent need for action, the nephrology field is considered to be in a state of stagnation regarding the management of chronic kidney disease patients who still experience unacceptably high morbidity and mortality. Ironically and paradoxically in a field lacking robust clinical trials, clinical practice is driven by guidelines-based medicine on weak evidence. The Emperor's syndrome, referring to Hans Christian Andersen's fairy tale, has been described in medicine as voluntary blindness to an obvious truth, being a weak evidence-based therapeutic intervention or weak health care. A promising positive example of improving heart and kidney outcomes is the emerging treatment with sodium-glucose cotransporter 2 inhibitors. COVID-19 could boost actions for patient-centered care as a positive shift in nephrology care.

摘要

新型冠状病毒肺炎(COVID-19)大流行给我们敲响了警钟,促使全球做出应对。卫生政策和实践在人力和财务成本方面受到了特别关注。在COVID-19之前,慢性肾脏病就已被视为糖尿病和高血压患者的风险倍增因素,而这两种疾病现在是COVID-19感染和不良结局的主要风险因素。与采取行动的迫切需求形成对比的是,在慢性肾脏病患者的管理方面,肾脏病领域被认为处于停滞状态,这些患者的发病率和死亡率仍然高得令人无法接受。具有讽刺意味的是,在一个缺乏有力临床试验的领域,临床实践却由基于证据薄弱的指南医学驱动。“皇帝综合征”,指的是汉斯·克里斯汀·安徒生的童话故事,在医学上被描述为对明显事实的自愿视而不见,即基于薄弱证据的治疗干预或薄弱的医疗保健。改善心脏和肾脏结局的一个有希望的积极例子是新型的钠-葡萄糖协同转运蛋白2抑制剂治疗。COVID-19可能会推动以患者为中心的护理行动,成为肾脏病护理的积极转变。