Rubinstein I, Mullen J B, Hoffstein V
Toronto Hospital, Ontario, Canada.
Arch Intern Med. 1988 Apr;148(4):813-6.
The usefulness of transbronchial biopsy in diagnosing idiopathic pulmonary alveolar lipoproteinosis (PAL) is not emphasized in the literature. Therefore, we decided to reassess our approach to the morphologic diagnosis of this disorder in 14 patients diagnosed over the past 13 years in two major teaching hospitals in Toronto. The morphologic diagnosis of idiopathic PAL was established by means of open lung biopsy in 11 patients; the use of transbronchial biopsy was not considered in eight of them. Transbronchial biopsy was performed in six patients, and the diagnosis of idiopathic PAL was reliably established in five cases. We conclude that transbronchial biopsy may be a worthwhile preliminary procedure to open lung biopsy in patients with suspected idiopathic PAL, and it can reliably establish the diagnosis in such cases.
经支气管活检在诊断特发性肺泡蛋白沉积症（PAL）中的作用在文献中未得到强调。因此，我们决定重新评估我们对过去13年在多伦多两家主要教学医院诊断出的14例该疾病患者进行形态学诊断的方法。11例患者通过开胸肺活检确立了特发性PAL的形态学诊断；其中8例未考虑使用经支气管活检。6例患者进行了经支气管活检，5例可靠地确立了特发性PAL的诊断。我们得出结论，对于疑似特发性PAL的患者，经支气管活检可能是开胸肺活检之前值得一试的程序，并且在这类病例中能够可靠地确立诊断。
