血清维生素E水平与妊娠期糖尿病：一项系统评价和荟萃分析。
Serum vitamin E level and gestational diabetes mellitus: a systematic review and meta-analysis.
作者信息
Sharifipour Foruzan, Abedi Parvin, Ciahkal Shahla Faal, Jahanfar Shayesteh, Mohaghegh Zeynab, Zahedian Maryam
机构信息
Midwifery Department, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
J Diabetes Metab Disord. 2020 Jul 4;19(2):1787-1795. doi: 10.1007/s40200-020-00582-5. eCollection 2020 Dec.
PURPOSE
Gestational diabetes mellitus (GDM) is one of the most common medical complications in pregnancy. This systematic review aimed to evaluate the association between vitamin E and GDM.
METHODS
Relevant articles from the Cochrane Library, PubMed, Scopus, Science Direct, Web of Science, and EMBASE databases up to December 2019 were searched. The inclusion criteria were observational full-text articles. The fixed and random effect models were used to analyze the pooled data using Review Manager 5.3.
RESULTS
Thirteen studies, including 596 participants, of whom 285 were diagnosed with GDM were included in the meta-analysis. The vitamin E level was significantly lower in women with GDM (MD: - 0.10; 95% CI: [-0.15, - 0.05]). The level of vitamin E was not different between overweight women with GDM and healthy pregnant women (MD: 0.03; 95% CI: [-0.08, 0.013]). The level of vitamin E was significantly lower in the third trimester of pregnancy in GDM women in comparison to the healthy pregnant women(MD: -0.09; 95% CI: [-0.12, -0.06]).
CONCLUSION
This study showed that the level of vitamin E is significantly lower in GDM women compared to healthy pregnant women.
目的
妊娠期糖尿病（GDM）是妊娠期间最常见的医学并发症之一。本系统评价旨在评估维生素E与GDM之间的关联。
方法
检索截至2019年12月Cochrane图书馆、PubMed、Scopus、Science Direct、Web of Science和EMBASE数据库中的相关文章。纳入标准为观察性全文文章。使用Review Manager 5.3软件，采用固定效应模型和随机效应模型对汇总数据进行分析。
结果
荟萃分析纳入了13项研究，共596名参与者，其中285人被诊断为GDM。GDM女性的维生素E水平显著较低（MD：-0.10；95%CI：[-0.15，-0.05]）。患有GDM的超重女性与健康孕妇的维生素E水平无差异（MD：0.03；95%CI：[-0.08，0.013]）。与健康孕妇相比，GDM女性在妊娠晚期的维生素E水平显著较低（MD：-0.09；95%CI：[-0.12，-0.06]）。
结论
本研究表明，与健康孕妇相比，GDM女性的维生素E水平显著较低。
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