Wang Juan, Wang Wenkang, Wang Hui, Tuo Biguang
Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Critical Care Medicine of the Third Affiliated Hospital (The First People's Hospital of Zunyi City), Zunyi Medical University, Zunyi, China.
Front Med (Lausanne). 2021 Jan 21;7:618256. doi: 10.3389/fmed.2020.618256. eCollection 2020.
Solute Carrier Family 26 (SLC26) is a conserved anion transporter family with 10 members in human (SLC26A1-A11, A10 being a pseudogene). All SLC26 genes except for SLC26A5 (prestin) are versatile anion exchangers with notable ability to transport a variety of anions. SLC26A6 has the most extensive exchange functions in the SLC26 family and is widely expressed in various organs and tissues of mammals. SLC26A6 has some special properties that make it play a particularly important role in ion homeostasis and acid-base balance. In the past few years, the function of SLC26A6 in the diseases has received increasing attention. SLC26A6 not only participates in the development of intestinal and pancreatic diseases but also serves a significant role in mediating nephrolithiasis, fetal skeletal dysplasia and arrhythmia. This review aims to explore the role of SLC26A6 in physiology and pathophysiology of relative mammalian organs to guide in-depth studies about related diseases of human.
溶质载体家族26（SLC26）是一个保守的阴离子转运体家族，在人类中有10个成员（SLC26A1 - A11，其中A10为假基因）。除SLC26A5（ Prestin）外，所有SLC26基因都是多功能阴离子交换体，具有运输多种阴离子的显著能力。SLC26A6在SLC26家族中具有最广泛的交换功能，在哺乳动物的各种器官和组织中广泛表达。SLC26A6具有一些特殊性质，使其在离子稳态和酸碱平衡中发挥特别重要的作用。在过去几年中，SLC26A6在疾病中的功能受到越来越多的关注。SLC26A6不仅参与肠道和胰腺疾病的发生发展，还在介导肾结石、胎儿骨骼发育不良和心律失常中发挥重要作用。本综述旨在探讨SLC26A6在相关哺乳动物器官生理和病理生理中的作用，以指导对人类相关疾病的深入研究。
