Deng Rongrong, Wang Changzheng, Ye Yi, Gou Liyao, Fu Zhongxiao, Ye Bo, Shao Feng, Zhang Xiaomei, Fu Weiyang, Xiao Jianping, Li Tao, Qi Huan, Li Chengbin
Pediatric Medical Center, The Second Clinical Medical College, Yangtze University, Jingzhou, China.
Department of Laboratory Medicine, The Second Clinical Medical College, Yangtze University, Jingzhou, China.
Ann Transl Med. 2021 Jan;9(1):62. doi: 10.21037/atm-20-7765.
Although there are many COVID-19 case series studies, few studies report the relationship between variations in blood cell parameters and inflammatory factors and disease severity. This study aims to describe the dynamic trends in COVID-19 blood cell parameters and inflammatory factors.
Ninety-two patients with confirmed COVID-19 at Jingzhou Central Hospital, Hubei Province, China, between January 23, 2020, and April 10, 2020, were enrolled. Epidemiological data, clinical information, and laboratory test results were collected and analyzed.
As patient age increased, disease severity increased (P<0.0001). The inflammatory factor C-reactive protein (CRP) showed a gradual increasing trend with disease aggravation. Based on dynamic change graphs, CRP in all patients with severe and critical COVID-19 initially increased and then decreased; however, CRP in patients with a good prognosis did not increase again after the initial decline (<20 mg/L). CRP in patients with a poor prognosis returned to a high level (>50 mg/L) 1 week after the initial decrease and continued to fluctuate at a high level. Lymphocyte count (LYM#) in patients with severe and critical disease was significantly lower (<1×10/L) than that in patients with moderate disease; LYM# was significantly increased 3 weeks after disease onset in patients with a good prognosis (>1×10/L), but patients with a poor prognosis continued to have a low LYM#.
CRP and LYM# showed strong correlation with disease progression, suggesting that these parameters could be used to monitor changes in patient condition.
尽管有许多关于新型冠状病毒肺炎（COVID-19）的病例系列研究，但很少有研究报道血细胞参数和炎症因子的变化与疾病严重程度之间的关系。本研究旨在描述COVID-19患者血细胞参数和炎症因子的动态变化趋势。
纳入2020年1月23日至2020年4月10日在中国湖北省荆州市中心医院确诊的92例COVID-19患者。收集并分析其流行病学数据、临床信息和实验室检查结果。
随着患者年龄的增加，疾病严重程度增加（P<0.0001）。炎症因子C反应蛋白（CRP）随着疾病加重呈逐渐上升趋势。根据动态变化图，所有重型和危重型COVID-19患者的CRP最初升高，然后下降；然而，预后良好的患者CRP在最初下降后（<20mg/L）未再次升高。预后较差的患者CRP在最初下降1周后恢复到高水平（>50mg/L），并持续在高水平波动。重型和危重型患者的淋巴细胞计数（LYM#）显著低于中型患者（<1×10/L）；预后良好的患者在发病3周后LYM#显著升高（>1×10/L），但预后较差的患者LYM#持续较低。
CRP和LYM#与疾病进展密切相关，提示这些参数可用于监测患者病情变化。
