Du Yanqing, Wang Xiang, Qin Zhonghua, Zhang Lixia
Department of Clinical Laboratory, Tianjin Haihe Hospital, Jinnan, Tianjin 300350, P.R. China.
Department of Prevention, Tianjin Haihe Hospital, Jinnan, Tianjin 300350, P.R. China.
Exp Ther Med. 2021 Jun;21(6):641. doi: 10.3892/etm.2021.10073. Epub 2021 Apr 16.
The present study aimed to investigate the diagnostic efficiency of the absolute number of lymphocytes (LYM) and creatine kinase (CK) levels in the diagnosis of coronavirus disease 2019 (COVID-19). For this, the clinical data from 84 patients with COVID-19 admitted to Tianjin Haihe Hospital (Tianjin, China) between January and February 2020 were collected. The patients were divided into the following groups: The common COVID-19 group (n=61) and severe COVID-19 group (n=23). In addition, 30 healthy subjects were included as a control group. The results demonstrated that the percentage of neutrophils (NEU%) was significantly increased, while the absolute number of white blood cells, LYM and the percentage of lymphocytes (LYM%) were significantly decreased in patients with COVID-19. Furthermore, in the severe group, the absolute number of red blood cells in female patients, the NEU%, the neutrophil-to-lymphocyte ratio (NLR) and the serum levels of interleukin-6 and C-reactive protein (CRP) were markedly elevated, while those of LYM and LYM% were significantly decreased (all P<0.05). In addition, in the receiver operating characteristics curve analysis for the combination of LYM + CK, the area under the curve values were 0.96 and 1.00, with a sensitivity of 95.08 and 100%, specificity of 86.67 and 100% and cut-off values of 0.42 and 0.50 for the common and severe COVID-19 group, respectively. The results indicated that the diagnostic efficiency of LYM + CK was higher than that of each single factor. Finally, a moderate correlation of lactate dehydrogenase with CRP and NLR (r=0.492 and 0.433, respectively; both P<0.05) was obtained. Overall, the results of the present study indicated that the values of LYM and CK were associated with the progression of COVID-19, suggesting that the combination of both factors may be of clinical diagnostic value for COVID-19.
本研究旨在探讨淋巴细胞绝对计数（LYM）和肌酸激酶（CK）水平在2019冠状病毒病（COVID-19）诊断中的效能。为此，收集了2020年1月至2月期间收治于天津市海河医院（中国天津）的84例COVID-19患者的临床资料。将患者分为以下几组：普通COVID-19组（n = 61）和重症COVID-19组（n = 23）。此外，纳入30名健康受试者作为对照组。结果显示，COVID-19患者中性粒细胞百分比（NEU%）显著升高，而白细胞、LYM绝对计数及淋巴细胞百分比（LYM%）显著降低。此外，在重症组中，女性患者红细胞绝对计数、NEU%、中性粒细胞与淋巴细胞比值（NLR）以及白细胞介素-6和C反应蛋白（CRP）血清水平显著升高，而LYM及LYM%显著降低（均P<0.05）。此外，在LYM + CK联合检测的受试者工作特征曲线分析中，普通和重症COVID-19组的曲线下面积值分别为0.96和1.00，灵敏度分别为95.08%和100%，特异性分别为86.67%和100%，截断值分别为0.42和0.50。结果表明，LYM + CK的诊断效能高于各单一因素。最后，乳酸脱氢酶与CRP和NLR呈中度相关（r分别为0.492和0.433；均P<0.05）。总体而言，本研究结果表明，LYM和CK值与COVID-19的病情进展相关，提示这两个因素联合检测可能对COVID-19具有临床诊断价值。
