Ogbebor Osakpolor, Mortimer Tatum D, Fryling Kyra, Zhang Jessica J, Bhanot Nitin, Grad Yonatan H
Division of Infectious Diseases, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Open Forum Infect Dis. 2020 Dec 18;8(2):ofaa632. doi: 10.1093/ofid/ofaa632. eCollection 2021 Feb.
infections have been increasing globally, with prevalence rising across age groups. In this study, we report a case of disseminated gonococcal infection (DGI) involving a prosthetic joint, and we use whole-genome sequencing to characterize resistance genes, putative virulence factors, and the phylogenetic lineage of the infecting isolate. We review the literature on sequence-based prediction of antibiotic resistance and factors that contribute to risk for DGI. We argue for routine sequencing and reporting of invasive gonococcal infections to aid in determining whether an invasive gonococcal infection is sporadic or part of an outbreak and to accelerate understanding of the genetic features of that contribute to pathogenesis.
全球范围内感染情况一直在增加，各年龄组的患病率都在上升。在本研究中，我们报告了一例累及人工关节的播散性淋球菌感染（DGI）病例，并使用全基因组测序来鉴定耐药基因、假定的毒力因子以及感染菌株的系统发育谱系。我们回顾了基于序列预测抗生素耐药性以及导致DGI风险的因素的文献。我们主张对侵袭性淋球菌感染进行常规测序和报告，以帮助确定侵袭性淋球菌感染是散发性的还是暴发的一部分，并加速对导致发病机制的基因特征的了解。
