Traoré Dipomin F, Sagna André B, Assi Serge B, Tchiekoi Bertin N'Cho, Adja Akré M, Dagnogo Mamadou, Koffi Alphonsine A, Rogier Christophe, Remoue Franck
Institut Pierre Richet (IPR), Institut National de la Santé Publique (INSP), Bouaké, Côte d'Ivoire.
MIVEGEC, University of Montpellier, IRD, CNRS, Montpellier, France.
Open Forum Infect Dis. 2020 Dec 30;8(2):ofaa635. doi: 10.1093/ofid/ofaa635. eCollection 2021 Feb.
Malaria is still a major public health concern in Côte d'Ivoire despite mass distribution of long-lasting insecticidal nets (LLINs) as a key preventive strategy. This study intended to evaluate the operational effectiveness of LLINs on the level of human-vector contact using 1 antibody-based biomarker of exposure to in urban areas.
This cross-sectional study collected socio-demographic data and use of LLINs from 9 neighborhoods in the city of Bouaké (Côte d'Ivoire). Dry blood spots performed in children aged >6 months and adults were used to evaluate immunoglobulin G (IgG) responses to the gSG6-P1 salivary peptide.
IgG response levels to the salivary peptide were significantly lower in individuals who declared having "always" (n = 270) slept under an LLIN compared with those who had "often" (n = 2087) and "never" (n = 88) slept under an LLIN ( < .0001). IgG response levels to gSG6-P1 between those who declared having "always" and "not always" slept under an LLIN varied according to neighborhood, socio-professional category, and age group.
The human IgG level to this gSG6-P1 salivary peptide could be a useful tool to evaluate the actual effectiveness of LLINs and help design behavioral change interventions that are crucial for sustaining universal coverage.
尽管科特迪瓦大量分发长效驱虫蚊帐（LLINs）作为一项关键预防策略，但疟疾仍是该国主要的公共卫生问题。本研究旨在利用一种基于抗体的城市地区暴露生物标志物，评估LLINs在人与病媒接触水平上的运行效果。
这项横断面研究收集了布瓦凯市（科特迪瓦）9个社区的社会人口统计学数据和LLINs的使用情况。对6个月以上儿童和成人采集的干血斑用于评估免疫球蛋白G（IgG）对冈比亚按蚊唾液肽gSG6-P1的反应。
与“经常”（n = 2087）和“从不”（n = 88）在LLIN下睡觉的人相比，宣称“总是”（n = 270）在LLIN下睡觉的个体对唾液肽的IgG反应水平显著较低（P <.0001）。宣称“总是”和“并非总是”在LLIN下睡觉的人之间对gSG6-P1的IgG反应水平因社区、社会职业类别和年龄组而异。
人类对这种gSG6-P1唾液肽的IgG水平可能是评估LLINs实际效果的有用工具，并有助于设计行为改变干预措施，这对于维持普遍覆盖至关重要。
