Alfsnes Kristian, Lagerqvist Nina, Vene Sirkka, Bohlin Jon, Verner-Carlsson Jenny, Ekqvist David, Bråve Andreas, Holmes Edward C, Shi Weifeng, Pettersson John H-O
Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden.
One Health. 2021 Jan 22;12:100217. doi: 10.1016/j.onehlt.2021.100217. eCollection 2021 Jun.
Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection.
与出血热相关的病原体通常源于人畜共患病。瑞典首例有记录的可能由病毒引起的严重出血热输入病例发生于1990年。尽管进行了广泛研究，但未确定病原体。对发病7至36天期间采集的样本进行全RNA测序并进行回顾性调查后，我们鉴定出登革病毒3型（DENV-3）和一种人pegivirus病毒（HPgV）。我们得出结论，该患者可能因非典型的严重且未确诊的登革热感染而出现出血症状。
