Kanakamedala R V, Kim R C, Reynolds G, Abadee P
Rehab Medicine Service, Veterans Administration Medical Center, Long Beach, CA 90822.
Arch Phys Med Rehabil. 1988 Apr;69(4):292-4.
Unilateral calf hypertrophy has been described in association with a variety of conditions. Bilateral neurogenic leg weakness with muscle wasting on one side and true hypertrophy on the other, however, has rarely been described. We report a 37-year-old heroin and alcohol abuser with a three-year history of weakness of the left leg and progressive enlargement of the right calf. Computed tomography of the right calf confirmed the presence of true hypertrophy. Electromyography showed denervation in the muscles of both legs. Nerve conduction studies were indicative of peripheral neuropathy. Biopsy of the gastrocnemius muscles revealed the presence of neurogenic atrophy on both sides, with marked hypertrophy and splitting of individual muscle fibers on the right. To our knowledge, this is only the second recorded case showing both muscle atrophy and muscle hypertrophy in response to denervation.
单侧小腿肥大已被描述与多种病症相关。然而，双侧神经源性腿部无力，一侧伴有肌肉萎缩而另一侧出现真正的肥大，这种情况很少被描述。我们报告了一名37岁的海洛因和酒精滥用者，有三年左腿无力和右小腿逐渐增大的病史。右小腿的计算机断层扫描证实存在真正的肥大。肌电图显示双腿肌肉存在失神经支配。神经传导研究表明存在周围神经病变。腓肠肌活检显示两侧均存在神经源性萎缩，右侧有明显的肥大和个别肌纤维分裂。据我们所知，这是有记录的第二例显示因失神经支配而出现肌肉萎缩和肌肉肥大的病例。
