Staples W G, Gétaz E P
S Afr Med J. 1977 Sep 3;52(11):438-43.
Historial aspects of the classification of large-cell lymphomas are described. Immunological characterization of the lymphomas has been made possible by identification of T and B lymphocytes according to their cell membrane surface characteristics. The pathogenesis of lymphomas has been clarified by the germinal (follicular) centre cell concepts of Lennert and Lukes and Collins. The various classifications are presented and compared. Whether these subdivisions will have any relevance in the clinical context remains to be seen.
本文描述了大细胞淋巴瘤分类的历史方面。根据T和B淋巴细胞的细胞膜表面特征进行识别，使得淋巴瘤的免疫特征得以明确。Lennert、Lukes和Collins提出的生发（滤泡）中心细胞概念阐明了淋巴瘤的发病机制。文中呈现并比较了各种分类。这些细分在临床背景下是否具有相关性仍有待观察。
