Rywlin A M
Am J Dermatopathol. 1980 Spring;2(1):17-25.
A brief historical review and a unifying classification of the non-Hodgkin's lymphomas are presented. The principles underlying this classification are that 1) neoplastic cells are named after normal cells they resemble most; 2) the germinal center is a reaction center where small lymphocytes undergo blastic transformation as well as the birthplace of small lymphocytes; and 3) lymphoid cells can be subdivided by size and cytologic characteristics into small, intermediate, and large types. This classification can be expanded by additional qualifying terms. Whether such expansions are justified in terms of reproducibility and clinical significance remains to be proven.
本文对非霍奇金淋巴瘤进行了简要的历史回顾并提出了统一的分类方法。该分类方法的基本原则如下：1）肿瘤细胞以与其最相似的正常细胞命名；2）生发中心是一个反应中心，小淋巴细胞在此经历母细胞转化，也是小淋巴细胞的发源地；3）淋巴细胞可根据大小和细胞学特征细分为小、中、大三种类型。这种分类可通过添加其他限定术语进行扩展。就可重复性和临床意义而言，这种扩展是否合理仍有待证明。
