SDE2和TIMELESS在活跃和停滞的DNA复制叉处的作用。
Roles of SDE2 and TIMELESS at active and stalled DNA replication forks.
作者信息
Lo Natalie, Rageul Julie, Kim Hyungjin
机构信息
Department of Pharmacological Sciences, The State University of New York at Stony Brook, Stony Brook, NY, USA.
Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
出版信息
Mol Cell Oncol. 2020 Dec 14;8(1):1855053. doi: 10.1080/23723556.2020.1855053. eCollection 2021.
Abstract
The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, maintains the integrity of the FPC, and together with TIM, protects stalled replication forks from nucleolytic degradation.
摘要
叉形保护复合体（FPC）由TIMELESS（TIM）-TIPIN异二聚体组成，作为复制体的支架来支持无缝DNA复制。我们最近发现，SDE2是一种与增殖细胞核抗原（PCNA）相关的DNA复制应激调节剂，它维持FPC的完整性，并与TIM一起保护停滞的复制叉不被核酸酶降解。
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