Wijayati Nanik, Lestari Lulua Romjanah, Wulandari Lisa Ayuningtyas, Mahatmanti F Widhi, Rakainsa Senda Kartika, Cahyono Edi, Wahab Roswanira Abdul
Department of Chemistry, Universitas Negeri Semarang, Semarang 50229, Central Java, Indonesia.
Perhutani Pine Chemical Industry, Pemalang 52319, Central Java, Indonesia.
Heliyon. 2021 Jan 30;7(1):e06058. doi: 10.1016/j.heliyon.2021.e06058. eCollection 2021 Jan.
Methoxylation is a relevant technological process applied in the production of high-value α-pinene derivatives. This report investigates the use of potassium alum [KAl(SO) · 12HO] as a catalyst in the methoxylation of α-pinene. In this study, the methoxylation reaction was optimized for the highest conversion of α-pinene and selectivity, assessed for the factors, catalyst loading (0.5; 1.0; and 1.5 g), volume ratio of α-pinene: methanol (1:4, 1:7, 1:10), reaction temperature (50, 55, 60 and 65 °C), and reaction time (72, 144, 216, 288, 360 min). The highest selectivity of KAl(SO)∙12HO in the methoxylation of α-pinene was achieved under an optimal condition of 1 g of catalyst loading, volume ratio of 1:10, as well as the reaction temperature and incubation time of 65 °C and 6 h, respectively. GC-MS results revealed the yields of the methoxylated products from the 98.2% conversion of α-pinene, to be 59.6%, 8.9%, and 7.1% for α-terpinyl methyl ether (TME), fenchyl methyl ether (FME), bornyl methyl ether (BME), respectively. It was apparent that a lower KAl(SO)∙12HO loading (0.5-1.5 g) was more economical for the methoxylation reaction. The findings seen here indicated the suitability of the KAl(SO) · 12HO to catalyze the methoxylation of α-pinene to produce an commercially important ethers.
甲氧基化是一种应用于高价值α-蒎烯衍生物生产的相关工艺过程。本报告研究了硫酸钾铝[KAl(SO₄)₂·12H₂O]作为α-蒎烯甲氧基化反应催化剂的应用。在本研究中，对甲氧基化反应进行了优化，以实现α-蒎烯的最高转化率和选择性，并评估了催化剂用量（0.5、1.0和1.5 g）、α-蒎烯与甲醇的体积比（1:4、1:7、1:10）、反应温度（50、55、60和65℃）以及反应时间（72、144、216、288、360分钟）等因素。在催化剂用量为1 g、体积比为1:10、反应温度为65℃且孵育时间为6小时的最佳条件下，实现了KAl(SO₄)₂∙12H₂O在α-蒎烯甲氧基化反应中的最高选择性。气相色谱-质谱（GC-MS）结果显示，α-蒎烯转化率为98.2%时，α-萜品基甲基醚（TME）、小茴香基甲基醚（FME）、冰片基甲基醚（BME）的甲氧基化产物产率分别为59.6%、8.9%和7.1%。显然，较低的KAl(SO₄)₂∙12H₂O用量（0.5 - 1.5 g）对甲氧基化反应更经济。此处的研究结果表明，KAl(SO₄)₂·12H₂O适用于催化α-蒎烯的甲氧基化反应，以生产具有商业重要性的醚类。
