Badawi Amani E, Elsheikh Sara S, Addeen Sarah Zaher, Soliman Mostafa A, Abd-Rabu Rami, Abdella Walid Shaban, Gad Elham A
Department of Ophthalmology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Faculty of Medicine, Zagazig University, Zagazig, Egypt.
J Curr Ophthalmol. 2020 Dec 12;32(4):315-328. doi: 10.4103/JOCO.JOCO_255_20. eCollection 2020 Oct-Dec.
To discuss the ocular manifestations provoked by novel coronavirus 2019 (COVID-19) disease in humans, the natural history of the disease in the eye, and its treatment.
We designed a narrative review of the ocular manifestations of COVID-19 based on the literature published till July 30, 2020. The databases were PubMed, Scopus, Cochrane Library, Google Scholar, and ScienceDirect. The inclusion criteria were (1) all types of clinical studies and (2) the topic was COVID-19 and its association to the eye regarding the current guidelines.
From 168 abstracts screened, 61 papers fully filled the inclusion criteria after the full-text screening. The 61 records include 13 case reports, 17 prospective (case series or cross-sectional) studies, 8 retrospective studies, 12 literature reviews (one systematic review), and 11 letters to the editor. The majority of the papers agreed that ophthalmic manifestations due to COVID-19 were few and rarely encountered. The main ocular pathology seemed to be conjunctivitis, where the viral polymerase chain reaction also happened to be most detectable. Posterior segment or neuro-ophthalmic manifestations were scarce. Viral genome detection in the eye as well as viral portal of entry to the globe is still vague.
The exact incidence of ocular manifestations in COVID-19 disease is uncertain. Conjunctivitis is the most prevalent ocular manifestation. It is still a debate whether the eye is a portal of entry for infection.
探讨2019年新型冠状病毒（COVID-19）感染人类后引发的眼部表现、该疾病在眼部的自然病程及其治疗方法。
我们基于截至2020年7月30日发表的文献，对COVID-19的眼部表现进行了叙述性综述。数据库包括PubMed、Scopus、Cochrane图书馆、谷歌学术和ScienceDirect。纳入标准为：（1）所有类型的临床研究；（2）主题为COVID-19及其与眼部的关联（符合当前指南）。
在筛选的168篇摘要中，61篇论文在全文筛选后完全符合纳入标准。这61条记录包括13篇病例报告、17篇前瞻性（病例系列或横断面）研究、8篇回顾性研究、12篇文献综述（1篇系统综述）和11篇给编辑的信。大多数论文一致认为，COVID-19引起的眼部表现较少且很少见。主要的眼部病理似乎是结膜炎，病毒聚合酶链反应在结膜炎中也最易检测到。后段或神经眼科表现较少。眼部病毒基因组检测以及病毒进入眼球的途径仍不明确。
COVID-19疾病中眼部表现的确切发生率尚不确定。结膜炎是最常见的眼部表现。眼睛是否为感染的入口仍存在争议。
