Department of Surgery, Footscray Hospital, Footscray, Victoria, Australia.
Melbourne Medical School - Western Health Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, St Albans, Victoria, Australia.
Cancer Rep (Hoboken). 2021 Jun;4(3):e1346. doi: 10.1002/cnr2.1346. Epub 2021 Feb 7.
The association between smoking, diabetes and obesity and oncological outcomes in patients with stage III colon cancer treated with surgery and adjuvant chemotherapy is unclear.
To evaluate whether smoking, obesity and diabetes are associated with the disease-free survival and overall survival rates of patients with stage III colon cancer who have received adjuvant chemotherapy.
Patients were selected from the prospectively maintained Australian Cancer Outcomes and Research Database (ACCORD). All stage III colon cancer patients who received adjuvant chemotherapy between January 2003 to December 2015 were retrospectively analyzed. The three primary exposures of interest were smoking status, body mass index (BMI) and diabetic (DM) status. The primary outcomes of interest were disease-free survival (DFS) and overall survival (OS).
A total of 785 patients between 2003 and 2015 were included for analysis. Using Kaplan-Meier survivorship curves, there was no association between OS and smoking (P = .71), BMI (P = .3) or DM (P = .72). Similarly, DFS did not reveal an association with smoking (P = .34), BMI (P = .2) and DM (P = .34). Controlling for other covariates the results did not reach statistical significance in adjusted multiple regression models.
Smoking, obesity and DM were not shown to influence DFS or OS for patients with stage III colon cancer who have received adjuvant chemotherapy.
吸烟、糖尿病和肥胖与接受手术和辅助化疗的 III 期结肠癌患者的肿瘤学结局之间的关系尚不清楚。
评估吸烟、肥胖和糖尿病是否与接受辅助化疗的 III 期结肠癌患者的无病生存率和总生存率相关。
患者从前瞻性维护的澳大利亚癌症结局和研究数据库（ACCORD）中选择。回顾性分析了 2003 年 1 月至 2015 年 12 月期间接受辅助化疗的所有 III 期结肠癌患者。三个主要暴露因素为吸烟状况、体重指数（BMI）和糖尿病（DM）状况。主要关注的结果是无病生存率（DFS）和总生存率（OS）。
2003 年至 2015 年期间共纳入 785 例患者进行分析。使用 Kaplan-Meier 生存曲线，OS 与吸烟（P=0.71）、BMI（P=0.3）或 DM（P=0.72）无关。同样，DFS 与吸烟（P=0.34）、BMI（P=0.2）和 DM（P=0.34）也没有关联。在调整后的多变量回归模型中，控制其他协变量后，结果没有达到统计学意义。
对于接受辅助化疗的 III 期结肠癌患者，吸烟、肥胖和 DM 并未显示影响 DFS 或 OS。
