Ma Yan-Qing, Liu Yu-Chen, Yin Cheng-Liang, Wang Li-Li, Liu Dai-Hong, Shi Jin-Long, Dou Li-Ping
Department of Hematology, First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China.
Department of Medical Big Data, First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Feb;29(1):9-16. doi: 10.19746/j.cnki.issn.1009-2137.2021.01.002.
To analyze the relationship between the expression level of SQLE and the prognosis of patients with acute myeloid leukemia (AML) through large sample data.
The data of genome, transcriptome, gene chip expression, and clinical information were statistically analyzed in multiple cohorts of AML patients with large samples.
It was found that the expression level of SQLE gene in tumor cells of AML patients was significantly higher than that of healthy controls (P=0.001). In the three AML corhort, the SQLE high expression group showed a worse therapeutic outcome (OS, P=0.009, P=0.0001, P=0.006; EFS, P=0.005, P=0.001). The unvariate and multivariate survival prognosis analysis indicated that the high expression of SQLE suggests lower event-free survival rate (EFS, HR=1.551, P<0.05) and overall survival rate (OS, HR=1.484, P<0.05). At the same time, it was also found that among different risk subgroups, the expression of SQLE in high risk group was higher (P<0.001, P=0.01), while the patients with high SQLE expression, who received allogeneic HSCT, had longer overall survival time (P=0.006).
The up-regulation SQLE expression suggests a poor prognosis for the patients with AML.
通过大样本数据分析鲨烯环氧酶（SQLE）表达水平与急性髓系白血病（AML）患者预后的关系。
对多组大样本AML患者的基因组、转录组、基因芯片表达及临床信息数据进行统计分析。
发现AML患者肿瘤细胞中SQLE基因的表达水平显著高于健康对照（P = 0.001）。在三个AML队列中，SQLE高表达组的治疗效果较差（总生存期，P = 0.009、P = 0.0001、P = 0.006；无事件生存期，P = 0.005、P = 0.001）。单因素和多因素生存预后分析表明，SQLE高表达提示无事件生存率（EFS，HR = 1.551，P < 0.05）和总生存率（OS，HR = 1.484，P < 0.05）较低。同时还发现，在不同风险亚组中，高危组的SQLE表达较高（P < 0.001，P = 0.01），而接受异基因造血干细胞移植的SQLE高表达患者总生存时间更长（P = 0.006）。
SQLE表达上调提示AML患者预后不良。
