47例结外NK/T细胞淋巴瘤患者的临床特征及预后分析
[Analysis on Clinical Characteristics and Prognosis of 47 Patients with Extranodal NK/T Cell Lymphoma].
作者信息
Li Qi-Hui, Yang Ping, Wang Ji-Jun, Dong Fei, Tian Lei, Wan Wei, Ke Xiao-Yan, Jing Hong-Mei
机构信息
Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
Department of Hematology, Peking University Third Hospital, Beijing 100191, China,E-mail:
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Feb;29(1):86-90. doi: 10.19746/j.cnki.issn.1009-2137.2021.01.014.
OBJECTIVE
To investigate the clinical features and prognostic factors of patients with extranodal NK/T cell lymphoma (ENKTL).
METHODS
The clinical data of patients with ENKTL from November 2009 to November 2019 was collected and retrospectively analyzed to clarify the clinical features of ENKTL, and evaluate the factors that affected survival and prognosis.
RESULTS
Forty-seven patients with ENKTL were collected, median age was 40 (12-82) years old, and more common in males than females, at the ratio of 1.47∶ 1. The median follow-up was 28 (1-112) months, and 5-year overall survival (OS) rate was 49.3%. The 5-year OS rates of the subjects with ECOG performance stage 0-1 and ≥2 were 51.6% and 0 (P=0.001), respectively. The 5-year OS rates of International Prognostic Index (IPI) score 0-1 and ≥2 were 60.0% and 40.6% (P=0.027), respectively. The 5-year OS rates of Ann Arbor staging Ⅰ/Ⅱ and stage Ⅲ/Ⅳ were 61.3% and 31.7% (P=0.005), respectively. The 5-year OS rates of the patients with presentation of B symptoms and without presentation of B symptoms were 79.0% and 30.1% (P=0.013), respectively. The 5-year OS rates of plasma EBV-DNA level < 5×10/ml and ≥ 5×10/ml were 60.4% and 33.3% (P=0.003), respectively. The 5-year OS rates of the patients receiving chemotherapy alone, combined chemotherapy and radiotherapy, and chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) were 12.9%, 86.5%, and 62.5% (P=0.001), respectively. Univariate analysis showed that ECOG score, IPI score, Ann Arbor staging, B symptoms, the copy number of EBV-DNA, and treatment regimens were statistically significant for OS. Multivariate analysis showed that ECOG score, B symptoms, the copy number of EBV-DNA, and treatment regimens were independent factors of ENKTL OS.
CONCLUSION
ECOG score, B symptoms, the copy number of EBV-DNA, and treatment regimens are independent prognostic factors for OS of patients with ENKTL.
目的
探讨结外NK/T细胞淋巴瘤（ENKTL）患者的临床特征及预后因素。
方法
收集2009年11月至2019年11月ENKTL患者的临床资料并进行回顾性分析，以明确ENKTL的临床特征，并评估影响生存及预后的因素。
结果
共收集47例ENKTL患者，中位年龄为40（12 - 82）岁，男性多于女性，比例为1.47∶1。中位随访时间为28（1 - 112）个月，5年总生存（OS）率为49.3%。ECOG体能状态0 - 1期和≥2期患者的5年OS率分别为51.6%和0（P = 0.001）。国际预后指数（IPI）评分0 - 1分和≥2分患者的5年OS率分别为60.0%和40.6%（P = 0.027）。Ann Arbor分期Ⅰ/Ⅱ期和Ⅲ/Ⅳ期患者的5年OS率分别为61.3%和31.7%（P = 0.005）。有B症状和无B症状患者的5年OS率分别为79.0%和30.1%（P = 0.013）。血浆EBV - DNA水平<5×10/ml和≥5×10/ml患者的5年OS率分别为60.4%和33.3%（P = 0.003）。单纯接受化疗、化疗联合放疗以及化疗后接受自体造血干细胞移植（auto - HSCT）患者的5年OS率分别为12.9%、86.5%和62.5%（P = 0.001）。单因素分析显示，ECOG评分、IPI评分、Ann Arbor分期、B症状、EBV - DNA拷贝数及治疗方案对OS有统计学意义。多因素分析显示，ECOG评分、B症状、EBV - DNA拷贝数及治疗方案是ENKTL患者OS的独立因素。
结论
ECOG评分、B症状、EBV - DNA拷贝数及治疗方案是ENKTL患者OS的独立预后因素。
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