Qiu Li-Hua, Tian Chen
Department of Hematology, Tianjin Medical University Cancer Institute & Hospital; National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Department of Hematology, Tianjin Medical University Cancer Institute & Hospital; National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China,E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Feb;29(1):297-300. doi: 10.19746/j.cnki.issn.1009-2137.2021.01.050.
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a very rare cutaneous malignant lymphoma derived from cytotoxic T cells that mainly involves subcutaneous adipose tissue rather than epidermis and dermis. It usually occurs in young and middle-aged population, and the etiology is currently unclear. Clinically, SPTCL is characterized by subcutaneous plaques, nodules, and skin ulcers with swell and ache, mainly presenting in limbs and trunk. SPTCL has been restricted to cases that express α/β phenotype, whereas cases with γ/δ phenotype are categorized to cutaneous γ/δ T cell lymphoma by WHO-EORTC classification. The standard treatment for SPTCL is not definite with a relatively good prognosis. The recent research progression of SPTCL is summarized in this review.
皮下脂膜炎样T细胞淋巴瘤（SPTCL）是一种非常罕见的皮肤恶性淋巴瘤，起源于细胞毒性T细胞，主要累及皮下脂肪组织而非表皮和真皮。它通常发生在中青年人群中，目前病因尚不清楚。临床上，SPTCL的特征是皮下斑块、结节和伴有肿胀及疼痛的皮肤溃疡，主要出现在四肢和躯干。SPTCL一直局限于表达α/β表型的病例，而γ/δ表型的病例根据世界卫生组织-欧洲肿瘤研究与治疗组织（WHO-EORTC）分类被归类为皮肤γ/δT细胞淋巴瘤。SPTCL的标准治疗方法尚不明确，但其预后相对较好。本文综述了SPTCL的最新研究进展。
