Epidemiology & Health Economics, GSK, Wavre, Belgium.
Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland.
Acta Paediatr. 2021 Jul;110(7):2040-2044. doi: 10.1111/apa.15800. Epub 2021 Feb 25.
A life-course immunisation approach is required to prevent and control pertussis. We aimed at reviewing pertussis incidence among infants in Denmark, Finland, Norway and Sweden, and at putting these data in the context of national surveillance systems and vaccination schedules.
We collected 2014-2018 data on pertussis incidence, on pertussis vaccination schedules and on coverage of the third dose of the diphtheria toxoid, tetanus toxoid and acellular pertussis vaccine from publicly available sources. We gathered opinions on national surveillance systems from public health and paediatrics experts of the relevant countries.
The pertussis vaccination schedules and coverage in infancy were similar across countries. All countries except Denmark recommended an additional booster vaccine dose for adolescents. None of the countries had maternal immunisation recommendation. Mean pertussis incidence in Denmark, Sweden and Finland was 168, 76 and 35 per 100,000 infant-years, respectively. Data were insufficient to derive a mean incidence in Norway. There were no systematic differences in the national surveillance systems across the countries.
The higher mean pertussis incidence in Denmark may be explained by the lack of recommendations for adolescent pertussis booster vaccination. Further investigations are warranted.
需要采取终身免疫接种方法来预防和控制百日咳。我们旨在回顾丹麦、芬兰、挪威和瑞典婴儿百日咳的发病率，并将这些数据置于国家监测系统和疫苗接种计划的背景下。
我们从公开来源收集了 2014-2018 年百日咳发病率、百日咳疫苗接种计划以及白喉类毒素、破伤风类毒素和无细胞百日咳疫苗第三剂覆盖率的数据。我们从相关国家的公共卫生和儿科专家那里收集了对国家监测系统的意见。
各国的百日咳疫苗接种计划和婴儿期覆盖率相似。除丹麦外，所有国家都建议为青少年接种额外的加强疫苗。没有一个国家建议对母亲进行免疫接种。丹麦、瑞典和芬兰的百日咳平均发病率分别为每 100,000 婴儿年 168、76 和 35 例。挪威的数据不足以得出平均发病率。各国的国家监测系统没有系统差异。
丹麦较高的百日咳平均发病率可能是由于缺乏青少年百日咳加强疫苗接种的建议所致。需要进一步调查。
