哺乳动物组织中的5-羟甲基胞嘧啶DNA糖基化酶活性。
5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue.
作者信息
Cannon S V, Cummings A, Teebor G W
机构信息
Department of Pathology, New York University School of Medicine, New York, NY 10016.
出版信息
Biochem Biophys Res Commun. 1988 Mar 30;151(3):1173-9. doi: 10.1016/s0006-291x(88)80489-3.
The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.
从T2噬菌体DNA中酶促释放5-羟甲基胞嘧啶是由小牛胸腺提取物实现的。与先前描述的5-羟甲基尿嘧啶DNA糖基化酶一样，在细菌提取物中未检测到5-羟甲基胞嘧啶DNA糖基化酶。这些活性的系统发育分布表明它们的主要功能是维持分化组织中甲基胞嘧啶残基。
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