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从进化角度看胰腺癌病理学。

Pancreatic cancer pathology viewed in the light of evolution.

机构信息

Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins University School of Medicine, Carnegie 415, 600 North Wolfe Street, Baltimore, MD, 21287, USA.

Sol Goldman Pancreatic Cancer Research Center, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

出版信息

Cancer Metastasis Rev. 2021 Sep;40(3):661-674. doi: 10.1007/s10555-020-09953-z. Epub 2021 Feb 8.

Abstract

One way to understand ductal adenocarcinoma of the pancreas (pancreatic cancer) is to view it as unimaginably large numbers of evolving living organisms interacting with their environment. This "evolutionary view" creates both expected and surprising perspectives in all stages of neoplastic progression. Advances in the field will require greater attention to this critical evolutionary prospective.

摘要

要理解胰腺导管腺癌(胰腺癌),可以将其视为数量惊人的不断进化的生物体与其环境相互作用。这种“进化观点”在肿瘤进展的所有阶段都产生了预期和意外的观点。该领域的进展将需要更多地关注这一关键的进化前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/253e/8556193/7a1834e3b9a6/10555_2020_9953_Fig1_HTML.jpg

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