Myers S R, Blake J W, Flesher J W
Department of Pharmacology, Albert B. Chandler Medical Center, University of Kentucky, Lexington.
Biochem Biophys Res Commun. 1988 Mar 30;151(3):1441-5. doi: 10.1016/s0006-291x(88)80523-0.
Anthracene undergoes biomethylation in rat liver cytosol preparations in vitro and in rat subcutaneous tissue, in vivo. The in vitro reaction is dependent on cytosol preparations fortified by the addition of S-adenosyl-L-methionine. The products of the reaction are the meso-anthracenic or L-region derivatives 9-methylanthracene and 9,10-dimethylanthracene. The latter compound may be the simplest polynuclear aromatic hydrocarbon carcinogen known. These reactive methylated metabolites are readily oxidized in cytosol preparations and in subcutaneous tissue, in vivo, to hydroxymethyl and formyl derivatives. Oxidation takes place mainly on the methyl groups since ring oxidized products were not detected.
蒽在体外大鼠肝脏胞液制剂以及体内大鼠皮下组织中会发生生物甲基化。体外反应依赖于添加S-腺苷-L-甲硫氨酸强化的胞液制剂。反应产物是中位蒽或L-区域衍生物9-甲基蒽和9,10-二甲基蒽。后一种化合物可能是已知最简单的多环芳烃致癌物。这些具有反应活性的甲基化代谢产物在胞液制剂和体内皮下组织中很容易被氧化为羟甲基和甲酰基衍生物。氧化主要发生在甲基上，因为未检测到环氧化产物。
