Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata, 997-8555, Japan.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia.
Chem Biodivers. 2021 Mar;18(3):e2000928. doi: 10.1002/cbdv.202000928. Epub 2021 Feb 8.
Nine new β-resorcylic acid derivatives, (15S)-de-O-methyllasiodiplodin (1), (13S,15S)-13-hydroxy-de-O-methyllasiodiplodin (2), (14S,15S)-14-hydroxy-de-O-methyllasiodiplodin (3), (13R,14S,15S)-13,14-dihydroxy-de-O-methyllasiodiplodin (4), ethyl (S)-2,4-dihydroxy-6-(8-hydroxynonyl)benzoate (5), ethyl 2,4-dihydroxy-6-(8-hydroxyheptyl)benzoate (6), ethyl 2,4-dihydroxy-6-(4-methoxycarbonylbutyl)benzoate (7), 3-(2-ethoxycarbonyl-3,5-dihydroxyphenyl)propionic acid (8), and isobutyl (S)-2,4-dihydroxy-6-(8-hydroxynonyl)benzoate (9), together with a known ethyl 2,4-dihydroxy-6-(8-oxononyl)benzoate (10) were obtained from Lasiodiplodia theobromae GC-22. The structures of these compounds were elucidated by extensive spectroscopic analyses. Compounds 1, 3, and 6 showed growth inhibitory effects against Digitaria ciliaris. Conversely, treatment with compounds 5, 6, 7, 9, and 10 stimulated elongation activity toward the root of Lactuca sativa. These data expand the repertoire of new β-resorcylic acid derivatives that may function as lead compounds in the synthesis of new agrochemical agents.
从热带炭疽菌 GC-22 中分离得到 9 个新的β-Resorcylic 酸衍生物，包括（15S）-去-O-甲基拉索地辛（1）、（13S，15S）-13-羟基去-O-甲基拉索地辛（2）、（14S，15S）-14-羟基去-O-甲基拉索地辛（3）、（13R，14S，15S）-13，14-二羟基去-O-甲基拉索地辛（4）、（S）-2,4-二羟基-6-（8-羟基壬基）苯甲酸乙酯（5）、2,4-二羟基-6-（8-羟基庚基）苯甲酸乙酯（6）、2,4-二羟基-6-（4-甲氧羰基丁基）苯甲酸乙酯（7）、3-（2-乙氧羰基-3,5-二羟基苯基）丙酸（8）和异丁基（S）-2,4-二羟基-6-（8-羟基壬基）苯甲酸乙酯（9），以及一个已知的 2,4-二羟基-6-（8-氧代壬基）苯甲酸乙酯（10）。这些化合物的结构通过广泛的光谱分析得到阐明。化合物 1、3 和 6 对狗尾草具有生长抑制作用。相反，化合物 5、6、7、9 和 10 处理后促进了莴苣根的伸长活性。这些数据扩展了新的β-Resorcylic 酸衍生物的种类，这些衍生物可能作为合成新型农药的先导化合物发挥作用。
