Department of Orthopedics, Sihong People's Hospital, Suqian, Jiangsu, 223900, PR China; Collaborative Innovation Center of Clinical Immunology Between Sihong People's Hospital and Soochow University, Jiangsu, PR China.
Collaborative Innovation Center of Clinical Immunology Between Sihong People's Hospital and Soochow University, Jiangsu, PR China; Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, 215123, PR China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu, 215123, PR China.
Mol Cell Probes. 2021 Apr;56:101705. doi: 10.1016/j.mcp.2021.101705. Epub 2021 Feb 6.
It is unclear what role does obesity (OB) index play between blood lipid and bone mineral density (BMD).
This study recruited a total of 4,558 Chinese elders >65 years. OB indices: waist circumference (WC), body mass index (BMI), waist-hip-ratio (WHR); blood lipid parameters: low density lipoprotein (LDL); total cholesterol (TC), triglyceride (TG), and BMDs at femur neck (FN), total hip (TH), and lumbar spine (LS) were measured. The t-test and multiple linear regression analysis were used to detect the differences of variables. Casual inference test (CIT) were performed to test potential mediators underlying the associations between blood lipid and BMD.
The blood lipids were positively associated with BMD (p < 0.05) after adjustment of age and sex (Model 1) both in total subjects and in sex-stratified subjects. The CIT showed that OB indices had significant mediation effects on the associations between blood lipid (TG and LDL) and BMD in total subjects and males. Comparably, the correlations of TG and BMD are most likely mediated by BMI and WC.
This study represented the first effort to report that OB indices, especially BMI and WC, served as significant mediators between blood lipid (TG and LDL) and BMD in Chinese elderly.
肥胖（OB）指数在血脂和骨密度（BMD）之间的作用尚不清楚。
本研究共招募了 4558 名中国 65 岁以上的老年人。OB 指数：腰围（WC）、体重指数（BMI）、腰臀比（WHR）；血脂参数：低密度脂蛋白（LDL）；总胆固醇（TC）、甘油三酯（TG）和股骨颈（FN）、全髋关节（TH）和腰椎（LS）的 BMD。采用 t 检验和多元线性回归分析检测变量差异。采用因果推理检验（CIT）检验血脂与 BMD 之间关联的潜在中介因素。
调整年龄和性别后（模型 1），总人群和性别分层人群的血脂与 BMD 呈正相关（p<0.05）。CIT 显示，OB 指数在总人群和男性中对血脂（TG 和 LDL）与 BMD 之间的关联具有显著的中介作用。相比之下，TG 和 BMD 的相关性最有可能由 BMI 和 WC 介导。
本研究首次报道 OB 指数，尤其是 BMI 和 WC，在血脂（TG 和 LDL）和中国老年人 BMD 之间的关联中起重要中介作用。
