Tsuiki K, Nagasawa J, Nakamura T
Tohoku J Exp Med. 1977 May;122(1):43-50. doi: 10.1620/tjem.122.43.
A method is described to determine the transcoronary circulatory transport function (h(t)) from input (Ci'(t)) and output (Co'(t)) dye-dilution curves obtained at the inlet and outlet of the coronary circulation. Assuming the mathematical linearity and stationarity of the coronary circulation, it is demonstrated that h(t) can be computed in terms of lagged normal density curve as a model from the sole measurement of the first to third moments of Ci'(t) and Co'(t) when recorded by a pair of our dye sampling systems that have shown to have identical response to step function. The method is useful because of its simplicity in practice. The physiological meaning of the determination of h(t) is discussed. It could be helpful to the estimation of the change in coronary path-length distribution under some conditions, although the method is still of limited value at present, because the averaged path-length through the coronary circulation cannot be evaluated correctly.
本文描述了一种从在冠状动脉循环的入口和出口处获得的输入（Ci'(t)）和输出（Co'(t)）染料稀释曲线来确定跨冠状动脉循环运输功能（h(t)）的方法。假设冠状动脉循环具有数学线性和平稳性，结果表明，当由一对对阶跃函数具有相同响应的染料采样系统记录时，h(t)可以根据滞后正态密度曲线作为模型，仅通过测量Ci'(t)和Co'(t)的一阶到三阶矩来计算。该方法在实践中因其简单性而有用。讨论了确定h(t)的生理学意义。尽管目前该方法仍有一定局限性，因为无法正确评估通过冠状动脉循环的平均路径长度，但在某些条件下，它可能有助于估计冠状动脉路径长度分布的变化。
