Tsuiki K, Sato Y, Sudo K, Nagasawa J
Tohoku J Exp Med. 1978 Dec;126(4):377-83. doi: 10.1620/tjem.126.377.
Transcoronary circulatory transport function was computed from the dye-dilution curves recorded simultaneously at the entrance (aortic root) and exit (coronary sinus) of the coronary circulation after the injection of dye bolus into the femoral vein in open-chest dog. The effect of coronary perfusion pressure and flow on the first (delta-t) and second (deltapi2) moments of the transport function was examined before and during intra-aortic angiotensin infusion. It was observed that the relative dispersion (deltapi2 1/2/delta-t) in the canine coronary circulation is the largest among the organ-circulations that have been examined by the investigators, suggesting that cardiac wall is highly heterogeneously perfused, and that the relative dispersion was variable depending on the coronary perfusion pressure and flow. It is concluded that sole measurement of the moment of transcoronary transport function such as -t cannot be a reliable indicator of the coronary circulatory disturbances. The underlying mechanisms for the dependency of the relative dispersion on the perfusion was discussed.
在开胸犬股静脉注射染料团后，根据在冠状动脉循环入口（主动脉根部）和出口（冠状窦）同时记录的染料稀释曲线计算冠状动脉循环转运功能。在主动脉内输注血管紧张素之前和期间，研究了冠状动脉灌注压力和流量对转运功能的一阶矩（δ-t）和二阶矩（δπ2）的影响。观察到，在研究人员检查过的器官循环中，犬冠状动脉循环中的相对离散度（δπ2 1/2/δ-t）最大，这表明心脏壁的灌注高度不均匀，并且相对离散度随冠状动脉灌注压力和流量而变化。得出的结论是，仅测量冠状动脉转运功能的矩，如δ-t，不能作为冠状动脉循环紊乱的可靠指标。讨论了相对离散度对灌注依赖性的潜在机制。
