Tolliver G A, Sadeghi K G, Samson H H
Alcoholism and Drug Abuse Institute, University of Washington, Seattle 98105.
Alcohol. 1988 Jan-Feb;5(1):9-13. doi: 10.1016/0741-8329(88)90036-5.
Lever responding maintained with ethanol reinforcement at concentrations up to 20% (v/v) was initiated in non-food and -water deprived rats via a sucrose-fading procedure. Home cage two-bottle preference tests between water and 10% ethanol were conducted before (pre) and after (post) the ethanol initiation procedure to determine the effect of initial ethanol preference on ethanol initiation and of initiation on later ethanol preference. Initial preference testing found that the rats could be divided into two groups, animals with low ethanol preference scores (preference below 25%) and those with moderate ethanol preference scores (preference between 25% and 50%). All animals were successfully initiated with the sucrose-fading procedure to lever press with ethanol reinforcement. Following initiation, home cage preference was markedly increased for the initially low-preferring rats (from 12% to 43%), while moderate-preferring rats showed only slight increases (from 37% to 47%). The shift in ethanol preference was discussed in terms of the relation between ethanol preference and behavioral history.
通过蔗糖消退程序，在未剥夺食物和水的大鼠中启动了杠杆反应，该反应由浓度高达20%（体积/体积）的乙醇强化维持。在乙醇启动程序之前（预）和之后（后），进行了水和10%乙醇之间的笼内双瓶偏好测试，以确定初始乙醇偏好对乙醇启动的影响以及启动对后期乙醇偏好的影响。初始偏好测试发现，大鼠可分为两组，乙醇偏好得分低的动物（偏好低于25%）和乙醇偏好得分中等的动物（偏好介于25%和50%之间）。所有动物都通过蔗糖消退程序成功启动了以乙醇强化的杠杆按压。启动后，最初偏好低的大鼠在笼内的偏好显著增加（从12%增至43%），而偏好中等的大鼠仅略有增加（从37%增至47%）。根据乙醇偏好与行为史之间的关系，对乙醇偏好的变化进行了讨论。
