State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Biomed Pharmacother. 2021 May;137:111317. doi: 10.1016/j.biopha.2021.111317. Epub 2021 Feb 5.
Long non-coding RNAs (lncRNAs) regulate gene expression and carcinogenesis. The lncRNA heart and neural crest derivatives expressed transcript 2 antisense RNA 1 (HAND2‑AS1) suppresses tumor growth, and its expression level was lower in tumor tissues than in adjacent normal tissues of most types of human cancers, including non-small cell lung cancer, ovarian cancer, breast cancer, gastric cancer, colorectal cancer, cervical cancer, endometrial cancer, prostate cancer, and esophagus squamous cell carcinoma. However, one study reported that the HAND2‑AS1 expression was upregulated in hepatocellular carcinoma tissues comparing with non-tumor tissues and it promoted tumor development. The aberrant expression of HAND2-AS1 was strongly linked to tumor progression and prognosis. Moreover, HAND2-AS1 was involved in tumor cell proliferation, differentiation, apoptosis, and cellular glucose metabolism. This review summarizes data on the expression profile, functions, underlying mechanism, and clinical value of HAND2-AS1 in cancer. The expression profile of HAND2-AS1 in 33 tumors was evaluated by bioinformatics analysis of The Cancer Genome Atlas.
长链非编码 RNA（lncRNA）调节基因表达和致癌作用。lncRNA 心脏和神经嵴衍生物表达转录本 2 反义 RNA 1（HAND2-AS1）抑制肿瘤生长，其在大多数类型的人类癌症（包括非小细胞肺癌、卵巢癌、乳腺癌、胃癌、结直肠癌、宫颈癌、子宫内膜癌、前列腺癌和食管鳞状细胞癌）的肿瘤组织中的表达水平低于相邻正常组织。然而，有一项研究报道，HAND2-AS1 在肝癌组织中的表达水平高于非肿瘤组织，并促进了肿瘤的发展。HAND2-AS1 的异常表达与肿瘤的进展和预后密切相关。此外，HAND2-AS1 参与肿瘤细胞的增殖、分化、凋亡和细胞葡萄糖代谢。本综述总结了 HAND2-AS1 在癌症中的表达谱、功能、潜在机制和临床价值的数据。通过对癌症基因组图谱的生物信息学分析，评估了 HAND2-AS1 在 33 种肿瘤中的表达谱。
