Srinivasan S R, Spahn S, Chiang Y K, Radhakrishnamurthy B, Berenson G S
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Biochem Med Metab Biol. 1988 Feb;39(1):31-9. doi: 10.1016/0885-4505(88)90055-2.
The influence of partial replacement of starch by sucrose on dietary cholesterol-induced serum lipoprotein responses was examined in 10 male cynomolgus monkeys (Macaca fascicularis). In a crossover design two semipurified diets provided either starch or starch and sucrose (1:1) as carbohydrate (49% by calories) with 0.4 mg cholesterol/kcal. Six weeks of starch + sucrose diet resulted in significantly reduced levels (mean +/- SE, mg/dl) of serum total cholesterol (264 +/- 9 vs 244 +/- 8) and apo B (110 +/- 6 vs 96 +/- 6) when compared with starch diet, whereas serum triglyceride levels remained similar between diets. With respect to changes in lipids and apolipoproteins (A-I or B) of very low (VLDL), low (LDL), intermediate (IDL), and high (HDL) density lipoproteins, starch + sucrose diet significantly increased VLDL-apo B (+34%), and decreased LDL-cholesterol (-18%) and LDL-apo B (-15%) as compared with starch alone; no differences were found in IDL and HDL between diets. The relative proportion of starch to sucrose in a diet appears to influence the magnitude of response of lipoproteins to dietary cholesterol.
在10只雄性食蟹猴（猕猴属）中研究了用蔗糖部分替代淀粉对膳食胆固醇诱导的血清脂蛋白反应的影响。采用交叉设计，两种半纯化日粮分别提供淀粉或淀粉与蔗糖（1:1）作为碳水化合物（占热量的49%），胆固醇含量为0.4毫克/千卡。与淀粉日粮相比，六周的淀粉 + 蔗糖日粮导致血清总胆固醇水平（平均值±标准误，毫克/分升）显著降低（264±9对244±8）和载脂蛋白B水平降低（110±6对96±6），而日粮之间的血清甘油三酯水平保持相似。关于极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、中间密度脂蛋白（IDL）和高密度脂蛋白（HDL）的脂质和载脂蛋白（A-I或B）的变化，与单独的淀粉日粮相比，淀粉 + 蔗糖日粮显著增加了VLDL-载脂蛋白B（+34%），并降低了LDL-胆固醇（-18%）和LDL-载脂蛋白B（-15%）；日粮之间在IDL和HDL方面未发现差异。日粮中淀粉与蔗糖的相对比例似乎会影响脂蛋白对膳食胆固醇反应的程度。
