Behall K M, Moser P B, Kelsay J L, Prather E S
Am J Clin Nutr. 1980 Apr;33(4):825-31. doi: 10.1093/ajcn/33.4.825.
The response of lipids in the blood between two groups of six young women was compared. Group 1 took oral contraceptives and group 2 had never taken oral contraceptives. Two experimental diets supplied about 13% of the calories from protein, 36% from fat, and 51% from carbohydrate. Of the carbohydrate, 84% was either sucrose or wheat starch. Each diet was fed for 4 weeks in a cross-over design. In the portion of the research presented here, subjects were fed a high sucrose meal before each dietary period and after weeks 1 and 3 of each dietary period. Blood lipids were measured before and 30, 60, 120, and 180 min after each meal. Cholesterol and lipoproteins were not affected by the sucrose meal, but free fatty acid levels decreased significantly in both groups. The serum levels of triglycerides, beta-lipoproteins, and cholesterol were significantly higher in users than in nonusers of oral contraceptives. Free fatty acid levels were affected by an interaction between diet and time, and the decrease in response was greater after the sucrose than after the wheat starch diet. Triglycerides, cholesterol, and total lipids were not significantly different after the two carbohydrate diets.
比较了两组六名年轻女性血液中脂质的反应。第一组服用口服避孕药，第二组从未服用过口服避孕药。两种实验饮食中，蛋白质提供约13%的热量，脂肪提供36%，碳水化合物提供51%。在碳水化合物中，84%是蔗糖或小麦淀粉。每种饮食以交叉设计喂养4周。在此处呈现的研究部分中，在每个饮食期之前以及每个饮食期的第1周和第3周后，给受试者喂食高蔗糖餐。在每餐前后以及餐后30、60、120和180分钟测量血脂。胆固醇和脂蛋白不受蔗糖餐的影响，但两组的游离脂肪酸水平均显著下降。口服避孕药使用者的血清甘油三酯、β-脂蛋白和胆固醇水平显著高于非使用者。游离脂肪酸水平受饮食和时间之间相互作用的影响，蔗糖饮食后反应的下降幅度大于小麦淀粉饮食后。两种碳水化合物饮食后，甘油三酯、胆固醇和总脂质无显著差异。
