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在秘鲁的资源匮乏环境下推行个性化医疗所面临的挑战。

Challenges to Bringing Personalized Medicine to a Low-Resource Setting in Peru.

机构信息

Universidad Católica Los Ángeles de Chimbote, Instituto de Investigación, Chimbote 02804, Peru.

Department of Medical Genetics, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, 0424 Oslo, Norway.

出版信息

Int J Environ Res Public Health. 2021 Feb 4;18(4):1470. doi: 10.3390/ijerph18041470.

DOI:10.3390/ijerph18041470
PMID:33557277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7922680/
Abstract

We provide an overview of the challenges that low-resource setting cities are facing, including a lack of global implementation of cancer screening programs, accurate data and statistics that may aid the health authorities and guide future public health activities, as well as reorient strategies, interventions and budgets to promote lifestyles that help prevent disease. Current cancer care does not fully reflect ethnic, cultural, environmental and resource differences. Herein, we described a snapshot of the cancer mortality and morbidity from a hospital that cares a rural and low-income population from Peru, called Chimbote (316,966 inhabitants) and showed the limitation of access to oncological care and genetic services. The city is located in the region of Ancash, which is a department of Northern Peru. Of note, we identified a greater proportion of cancer cases than previously described, with a young age of onset and differential profile of the most frequent cancers. With the emergence of increasingly effective interventions, it becomes paramount that populations living in resource-limited settings have access to cancer services and participate in genetics and genomic research.

摘要

我们提供了一个概述,介绍了资源匮乏环境下的城市所面临的挑战,包括癌症筛查计划在全球范围内的实施不足、缺乏可能有助于卫生当局和指导未来公共卫生活动的准确数据和统计数据,以及重新调整策略、干预措施和预算,以促进有助于预防疾病的生活方式。目前的癌症治疗并未充分反映种族、文化、环境和资源差异。在此,我们描述了秘鲁一个名为 Chimbote(有 316,966 名居民)的医院所照顾的农村和低收入人群的癌症死亡率和发病率的快照,并展示了获得肿瘤治疗和遗传服务的局限性。该城市位于秘鲁北部的安卡什地区。值得注意的是,我们发现癌症病例的比例高于之前的描述,发病年龄较早,最常见癌症的类型也存在差异。随着越来越有效的干预措施的出现,生活在资源有限环境中的人群获得癌症服务并参与遗传学和基因组研究变得至关重要。

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A snapshot of current genetic testing practice in Lynch syndrome: The results of a representative survey of 33 Latin American existing centres/registries.林奇综合征当前基因检测实践概览:对 33 个拉丁美洲现有中心/登记处的代表性调查结果。
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