糖尿病自主神经病变中的QT间期延长：在心脏性猝死中可能起的作用？
Prolonged QT period in diabetic autonomic neuropathy: a possible role in sudden cardiac death?
作者信息
Bellavere F, Ferri M, Guarini L, Bax G, Piccoli A, Cardone C, Fedele D
机构信息
Istituto di Medicina Interna, Cattedra di Patologia Medica Policlinico, Padua, Italy.
出版信息
Br Heart J. 1988 Mar;59(3):379-83. doi: 10.1136/hrt.59.3.379.
Abstract
Twenty four men with insulin dependent diabetes and different degrees of autonomic neuropathy were studied to establish the response of the QT interval to various heart rates. Nine men with autonomic neuropathy had a longer QT interval than 13 healthy individuals and 15 patients who had diabetes without, or with only mild, autonomic neuropathy. Those with autonomic neuropathy also had a proportionally greater lengthening of the QT interval for a given increase in RR interval. The results of this study suggest a basis for the finding that sudden death is more common in patients with diabetic autonomic neuropathy.
摘要
对24名胰岛素依赖型糖尿病且伴有不同程度自主神经病变的男性进行了研究，以确定QT间期对各种心率的反应。9名患有自主神经病变的男性的QT间期比13名健康个体以及15名无自主神经病变或仅患有轻度自主神经病变的糖尿病患者更长。对于给定的RR间期增加，患有自主神经病变的患者QT间期的延长比例也更大。这项研究的结果为糖尿病自主神经病变患者猝死更为常见这一发现提供了依据。
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