糖尿病自主神经病变中的QT间期延长：在心脏性猝死中可能起的作用？
Prolonged QT period in diabetic autonomic neuropathy: a possible role in sudden cardiac death?
作者信息
Bellavere F, Ferri M, Guarini L, Bax G, Piccoli A, Cardone C, Fedele D
机构信息
Istituto di Medicina Interna, Cattedra di Patologia Medica Policlinico, Padua, Italy.
出版信息
Br Heart J. 1988 Mar;59(3):379-83. doi: 10.1136/hrt.59.3.379.
Abstract
Twenty four men with insulin dependent diabetes and different degrees of autonomic neuropathy were studied to establish the response of the QT interval to various heart rates. Nine men with autonomic neuropathy had a longer QT interval than 13 healthy individuals and 15 patients who had diabetes without, or with only mild, autonomic neuropathy. Those with autonomic neuropathy also had a proportionally greater lengthening of the QT interval for a given increase in RR interval. The results of this study suggest a basis for the finding that sudden death is more common in patients with diabetic autonomic neuropathy.
摘要
对24名胰岛素依赖型糖尿病且伴有不同程度自主神经病变的男性进行了研究，以确定QT间期对各种心率的反应。9名患有自主神经病变的男性的QT间期比13名健康个体以及15名无自主神经病变或仅患有轻度自主神经病变的糖尿病患者更长。对于给定的RR间期增加，患有自主神经病变的患者QT间期的延长比例也更大。这项研究的结果为糖尿病自主神经病变患者猝死更为常见这一发现提供了依据。
相似文献
1
Prolonged QT period in diabetic autonomic neuropathy: a possible role in sudden cardiac death?糖尿病自主神经病变中的QT间期延长：在心脏性猝死中可能起的作用？
Br Heart J. 1988 Mar;59(3):379-83. doi: 10.1136/hrt.59.3.379.
2
Evaluation of QT interval length, QT dispersion and myocardial m-iodobenzylguanidine uptake in insulin-dependent diabetic patients with and without autonomic neuropathy.胰岛素依赖型糖尿病伴或不伴自主神经病变患者的QT间期长度、QT离散度及心肌间碘苄胍摄取情况评估。
Clin Sci (Lond). 1997 Oct;93(4):325-33. doi: 10.1042/cs0930325.
3
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy.糖尿病自主神经病变中的QT间期延长与心源性猝死
J Clin Endocrinol Metab. 1987 Apr;64(4):751-4. doi: 10.1210/jcem-64-4-751.
4
Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients.
Diabetologia. 1991 Mar;34(3):182-5. doi: 10.1007/BF00418273.
5
QT prolongation on the electrocardiogram in diabetic autonomic neuropathy.糖尿病性自主神经病变时心电图QT间期延长
Diabet Med. 1990 Feb;7(2):105-10. doi: 10.1111/j.1464-5491.1990.tb01342.x.
6
7
The clinical utility of QT interval assessment in diabetes.QT间期评估在糖尿病中的临床应用
Diabetes Nutr Metab. 2000 Dec;13(6):356-65.
8
[Corrected QT interval and diabetic neuropathy of the cardiovascular system].[校正QT间期与心血管系统糖尿病性神经病变]
Przegl Lek. 1995;52(12):583-7.
9
[QT dispersion in insulin-dependent diabetics].[胰岛素依赖型糖尿病患者的QT离散度]
G Ital Cardiol. 1999 Jun;29(6):675-8.
10
Circadian rhythmicity of heart rate and QTc interval in diabetic autonomic neuropathy: implications for the mechanism of sudden death.糖尿病自主神经病变中心率与QTc间期的昼夜节律：对猝死机制的启示
Am Heart J. 1993 Mar;125(3):744-52. doi: 10.1016/0002-8703(93)90166-7.
引用本文的文献
1
Complications during Adolescence Predict Mortality in Young Adults with Childhood Onset Type 1 Diabetes.青春期并发症可预测儿童期起病的1型糖尿病青年患者的死亡率。
Pediatr Diabetes. 2024 Apr 12;2024:8194756. doi: 10.1155/2024/8194756. eCollection 2024.
2
Molecular Mechanisms and Epigenetic Regulation in Diabetic Cardiomyopathy.糖尿病心肌病的分子机制与表观遗传调控
Front Cardiovasc Med. 2021 Dec 16;8:725532. doi: 10.3389/fcvm.2021.725532. eCollection 2021.
3
Electrical Features of the Diabetic Myocardium. Arrhythmic and Cardiovascular Safety Considerations in Diabetes.糖尿病心肌的电学特征。糖尿病中的心律失常及心血管安全性考量。
Front Pharmacol. 2021 Jul 8;12:687256. doi: 10.3389/fphar.2021.687256. eCollection 2021.
4
Molecular and Electrophysiological Role of Diabetes-Associated Circulating Inflammatory Factors in Cardiac Arrhythmia Remodeling in a Metabolic-Induced Model of Type 2 Diabetic Rat.糖尿病相关循环炎症因子在代谢诱导的 2 型糖尿病大鼠心律失常重构中的分子和电生理作用。
Int J Mol Sci. 2021 Jun 25;22(13):6827. doi: 10.3390/ijms22136827.
5
Prevalence of cardiovascular autonomic neuropathy and gastroparesis symptoms among patients with type 2 diabetes who attend a primary health care center.在前往基层医疗中心就诊的 2 型糖尿病患者中，心血管自主神经病变和胃轻瘫症状的患病率。
PLoS One. 2018 Dec 21;13(12):e0209500. doi: 10.1371/journal.pone.0209500. eCollection 2018.
6
QTc prolongation in Black diabetic subjects with cardiac autonomic neuropathy.患有心脏自主神经病变的黑人糖尿病患者的QTc间期延长。
Afr Health Sci. 2017 Dec;17(4):1092-1100. doi: 10.4314/ahs.v17i4.17.
7
Prolonged Tp-e Interval, Tp-e/QT Ratio and Tp-e/QTc Ratio in Patients with Type 2 Diabetes Mellitus.2 型糖尿病患者的 Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值。
Endocrinol Metab (Seoul). 2016 Mar;31(1):105-12. doi: 10.3803/EnM.2016.31.1.105.
8
Associations between changes in city and address specific temperature and QT interval--the VA Normative Aging Study.城市及特定住址温度变化与QT间期的关联——退伍军人事务部标准老化研究
PLoS One. 2014 Sep 19;9(9):e106258. doi: 10.1371/journal.pone.0106258. eCollection 2014.
9
Greater insulin resistance indicates decreased diurnal variation in the QT interval in patients with type 2 diabetes.胰岛素抵抗增强表明2型糖尿病患者QT间期的昼夜变化减小。
Heart Vessels. 2014 Mar;29(2):256-62. doi: 10.1007/s00380-013-0356-8. Epub 2013 May 17.
10
Pharmacometabolomic approach to predict QT prolongation in guinea pigs.基于代谢组学的豚鼠 QTc 延长预测方法。
PLoS One. 2013 Apr 4;8(4):e60556. doi: 10.1371/journal.pone.0060556. Print 2013.
本文引用的文献
1
The normal Q-T interval.正常Q-T间期。
Am Heart J. 1962 Jun;63:747-53. doi: 10.1016/0002-8703(62)90059-5.
2
The natural history of diabetic autonomic neuropathy.糖尿病自主神经病变的自然病史。
Q J Med. 1980 Winter;49(193):95-108.
3
Sleep apnoea in diabetic patients with autonomic neuropathy.糖尿病自主神经病变患者的睡眠呼吸暂停
J R Soc Med. 1981 Mar;74(3):192-5. doi: 10.1177/014107688107400306.
4
Influence of heart rate and inhibition of autonomic tone on the QT interval.心率及自主神经张力抑制对QT间期的影响。
Circulation. 1982 Mar;65(3):435-9. doi: 10.1161/01.cir.65.3.435.
5
Prolongation of the Q-T interval in man during sleep.人在睡眠期间Q-T间期延长。
Am J Cardiol. 1983 Jul;52(1):55-9. doi: 10.1016/0002-9149(83)90068-1.
6
Breathing, sleep, and diabetic autonomic neuropathy.呼吸、睡眠与糖尿病性自主神经病变
Diabetes. 1984 Nov;33(11):1025-7. doi: 10.2337/diab.33.11.1025.
7
Documented sudden cardiac death in prolonged QT syndrome.
Arch Intern Med. 1984 Apr;144(4):833-5.
8
Diagnosis and management of diabetic autonomic neuropathy.糖尿病自主神经病变的诊断与管理
Br Med J (Clin Res Ed). 1983 Jul 2;287(6384):61. doi: 10.1136/bmj.287.6384.61-a.
9
Cardiac arrest due to anesthesia. A study of incidence and causes.麻醉导致的心脏骤停。发病率及病因研究。
JAMA. 1985 Apr 26;253(16):2373-7.
10
Idiopathic long QT syndrome: progress and questions.特发性长QT综合征：进展与问题
Am Heart J. 1985 Feb;109(2):399-411. doi: 10.1016/0002-8703(85)90626-x.
Zotero 插件