Effect of surgical stimulation on the auditory evoked response.

Previous studies have shown a dose-related effect of a number of general anaesthetic agents on the early cortical waves in the auditory evoked response (AER). In this study the effect of surgical stimulation on these waves was examined in 11 patients anaesthetized with thiopentone, nitrous oxide and halothane and paralysed with pancuronium. The inspired nitrous oxide concentration and end-tidal halothane concentration were held constant at 70% and 0.3%, respectively, and baseline AER recordings were made. Following surgical stimulation there was a progressive and significant increase in the amplitude of waves Nb and Pb/Pc. Unambiguous autonomic responses were seen in three patients, but these were not significantly correlated with changes in the AER. We conclude from this, and previous studies, that the amplitude of cortical waves in the AER are sensitive not only to anaesthetic concentration but also to surgical stimulation. The AER may, therefore, provide a useful index of depth of anaesthesia, that is the balance between the effects of surgical stimulation and anaesthetic depression on central nervous system activity.