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用于下颌骨板体模的质子治疗

Proton Therapy for Mandibula Plate Phantom.

作者信息

Senirkentli Güler Burcu, Ekinci Fatih, Bostanci Erkan, Güzel Mehmet Serdar, Dağli Özlem, Karim Ahmed M, Mishra Alok

机构信息

Department of Pediatric Dentistry, Baskent University, Ankara 06810, Turkey.

Department of Physics, Gazi University, Ankara 06500, Turkey.

出版信息

Healthcare (Basel). 2021 Feb 4;9(2):167. doi: 10.3390/healthcare9020167.

Abstract

PURPOSE

In this study, the required dose rates for optimal treatment of tumoral tissues when using proton therapy in the treatment of defective tumours seen in mandibles has been calculated. We aimed to protect the surrounding soft and hard tissues from unnecessary radiation as well as to prevent complications of radiation. Bragg curves of therapeutic energized protons for two different mandible (molar and premolar) plate phantoms were computed and compared with similar calculations in the literature. The results were found to be within acceptable deviation values.

METHODS

In this study, mandibular tooth plate phantoms were modelled for the molar and premolar areas and then a Monte Carlo simulation was used to calculate the Bragg curve, lateral straggle/range and recoil values of protons remaining in the therapeutic energy ranges. The mass and atomic densities of all the jawbone layers were selected and the effect of layer type and thickness on the Bragg curve, lateral straggle/range and the recoil were investigated. As protons move through different layers of density, lateral straggle and increases in the range were observed. A range of energies was used for the treatment of tumours at different depths in the mandible phantom.

RESULTS

Simulations revealed that as the cortical bone thickness increased, Bragg peak position decreased between 0.47-3.3%. An increase in the number of layers results in a decrease in the Bragg peak position. Finally, as the proton energy increased, the amplitude of the second peak and its effect on Bragg peak position decreased.

CONCLUSION

These findings should guide the selection of appropriate energy levels in the treatment of tumour structures without damaging surrounding tissues.

摘要

目的

在本研究中,已计算出在下颌骨中所见的缺陷性肿瘤治疗中使用质子治疗时,肿瘤组织最佳治疗所需的剂量率。我们旨在保护周围的软硬组织免受不必要的辐射,并预防辐射并发症。计算了两种不同下颌骨(磨牙和前磨牙)板体模的治疗能量质子的布拉格曲线,并与文献中的类似计算进行了比较。结果发现处于可接受的偏差值范围内。

方法

在本研究中,对磨牙和前磨牙区域的下颌牙板体模进行建模,然后使用蒙特卡罗模拟来计算处于治疗能量范围内的质子的布拉格曲线、横向离散/射程和反冲值。选择了所有颌骨层的质量和原子密度,并研究了层类型和厚度对布拉格曲线、横向离散/射程和反冲的影响。随着质子穿过不同密度的层,观察到横向离散和射程增加。使用一系列能量来治疗下颌骨体模中不同深度的肿瘤。

结果

模拟显示,随着皮质骨厚度增加,布拉格峰位置下降了0.47 - 3.3%。层数增加会导致布拉格峰位置下降。最后,随着质子能量增加,第二个峰的幅度及其对布拉格峰位置的影响减小。

结论

这些发现应指导在不损伤周围组织的情况下治疗肿瘤结构时选择合适的能量水平。

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