Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC-Centre of Advanced Study, Panjab University, Chandigarh, India.
Expert Opin Ther Targets. 2021 Feb;25(2):115-139. doi: 10.1080/14728222.2021.1887141. Epub 2021 Mar 14.
: All psychiatric disorders exhibit excitotoxicity, mitochondrial dysfunction, inflammation, oxidative stress, and neural damage as their common characteristic. The endogenous nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is implicated in the defense mechanism against oxidative stress and has a significant role in psychiatric disorders.: We explore the role of Nrf2 pathway and its modulators in psychiatric disorders. The literature was searched utilizing various databases such as Embase, Medline, Web of Science, Pub-Med, and Google Scholar from 2010 to 2020. The search included research articles, clinical reports, systematic reviews, and meta-analyses.: Environmental factors and genetic predisposition can be a trigger for the development of psychiatric disorders. Nrf2 downregulates certain inflammatory pathways and upregulates various antioxidant enzymes to maintain a balance. However, its intricate balance with NF-Kβ (Nuclear factor kappa light chain enhancer of activated B cells) and its crosstalk with the transcription factor Nrf2 is critical in severe oxidative stress. Several Nrf2 modulators are now in clinical trials and can help reduce oxidative stress and neuroinflammation. There are immense potential opportunities for these modulators to become a novel therapeutic option.
: 所有精神障碍都表现出兴奋性毒性、线粒体功能障碍、炎症、氧化应激和神经损伤等共同特征。内源性核因子红细胞 2 相关因子 2（Nrf2）信号通路与抗氧化应激的防御机制有关，在精神障碍中具有重要作用。: 我们探讨了 Nrf2 通路及其调节剂在精神障碍中的作用。从 2010 年到 2020 年，我们利用 Embase、Medline、Web of Science、Pub-Med 和 Google Scholar 等各种数据库搜索文献。搜索包括研究文章、临床报告、系统评价和荟萃分析。: 环境因素和遗传易感性可能是精神障碍发展的诱因。Nrf2 下调某些炎症途径，上调各种抗氧化酶以保持平衡。然而，它与 NF-Kβ（激活 B 细胞的核因子 kappa 轻链增强子）的复杂平衡及其与转录因子 Nrf2 的相互作用在严重的氧化应激中至关重要。目前有几种 Nrf2 调节剂正在临床试验中，可帮助减轻氧化应激和神经炎症。这些调节剂具有成为新型治疗选择的巨大潜力。
