Department of Cardiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.
Department of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.
Pediatr Rheumatol Online J. 2021 Feb 8;19(1):12. doi: 10.1186/s12969-021-00494-5.
Kawasaki disease (KD) is a systemic vasculitis, and the formation of coronary artery lesions(CAL) is its most common sequela. Both genetic and environmental factors are considered to be important factors of in KD. Integrin α2 (ITGA2) is a transmembrane receptor that is associated with susceptibility to several diseases, but its relevance to KD with CAL is unclear.
We genotyped ITGA2 rs1126643 in 785 KD patients with the CAL and no-CAL(NCAL) (300 patients with CAL, and 485 age- and sex-matched patients with NCAL). OR (95% CI) and adjusted OR (95% CI) were used to evaluate the intensity of the association.
We found a significantly increased risk of KD with CAL associated with ITGA2 rs1126643 genotypes (CT vs CC: adjusted OR = 1.57, 95% CI = 1.16-2.12, P = 0.0032; CT/TT vs CC: adjusted OR = 1.49, 95% CI = 1.12-2.00, P = 0.0068; T vs C: adjusted OR = 1.66, 95% CI = 1.16-2.51, P = 0.0165). Moreover, we found that carriers of the CT/TT genotype had a significant risk of KD with coronary artery lesion susceptibility for children ≤60 months of age, and the CT/TT genotype was significantly associated with an increased risk of SCAL formation and MCAL formation when compared with the CC genotype.
ITGA2 rs1126643 was associated with increased susceptibility and severity of CAL in KD.
川崎病（KD）是一种全身性血管炎，冠状动脉损伤（CAL）是其最常见的后遗症。遗传和环境因素被认为是 KD 的重要因素。整合素 α2（ITGA2）是一种跨膜受体，与多种疾病的易感性有关，但它与 KD 合并 CAL 的相关性尚不清楚。
我们对 785 例 KD 患者（300 例合并 CAL，485 例年龄和性别匹配的无 CAL[NCAL]患者）进行了 ITGA2 rs1126643 基因分型。比值比（OR）（95%可信区间[CI]）和调整后的 OR（95%CI）用于评估关联强度。
我们发现，与 ITGA2 rs1126643 基因型相比，KD 合并 CAL 的风险显著增加（CT 与 CC：调整后的 OR=1.57，95%CI=1.16-2.12，P=0.0032；CT/TT 与 CC：调整后的 OR=1.49，95%CI=1.12-2.00，P=0.0068；T 与 C：调整后的 OR=1.66，95%CI=1.16-2.51，P=0.0165）。此外，我们发现 CT/TT 基因型携带者发生儿童≤60 个月 KD 合并冠状动脉损伤的风险显著增加，与 CC 基因型相比，CT/TT 基因型与 SCAL 和 MCAL 形成的风险增加显著相关。
ITGA2 rs1126643 与 KD 患者 CAL 易感性和严重程度增加相关。
